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著作: Hida Y/Kubo Y/Arase S/Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours./[The British Journal of Dermatology]

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EID
210563
EOID
654249
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LastModified
2012年8月28日(火) 21:42:23
Operator
大家 隆弘
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TRUE
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Owner
久保 宜明
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種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Hida Y
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kubo Y
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Arase S
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours.

副題 任意
要約 任意

(英) BACKGROUND: The activation of oncogenes is an important step in tumorigenesis, and recently, oncogene-induced senescence (OIS) was proposed as a critical barrier against malignant transformation in normal primary cells. OBJECTIVES: The aim of this study was to examine the activation of fibroblast growth factor receptor 3 (FGFR3) as an oncogene product and OIS in human skin tumours. METHODS: We investigated the activation of FGFR3 and OIS by mutation and immunohistochemical analysis in skin tumours, including seborrhoeic keratosis, actinic keratosis (AK), Bowen's disease (BD), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). RESULTS: Activated point mutations of FGFR3 were identified in four of 22 cases (18%) of seborrhoeic keratosis, but no mutation was detected in the other skin tumours. Twenty-seven of 31 cases (87%) of seborrhoeic keratosis showed moderately to strongly positive expression of the FGFR3 protein, but almost all the other skin tumours were negative. On the other hand, almost all the seborrhoeic keratoses showed negative immunoreactivity for antiphoshohistone H2AX (gamma-H2AX) as a marker of OIS, but 17 of 22 cases (77%) of AK were moderately to strongly positive. Immunoreactivity for gamma-H2AX was significantly greater in AK than in seborrhoeic keratosis, BD, BCC and SCC. CONCLUSIONS: The activation of FGFR3 might be a common feature in the tumorigenesis in seborrhoeic keratosis, although the activation does not induce a typical oncogenic signal in keratinocytes. In addition, OIS due to some oncogenic signals rather than activation of FGFR3 might be involved in the early skin carcinogenesis related to chronic ultraviolet radiation exposure.

キーワード 推奨
  1. (英) Bowen's Disease
  2. (英) Carcinoma, Basal Cell
  3. (英) Carcinoma, Squamous Cell
  4. (英) Chi-Square Distribution
  5. (英) Humans
  6. (英) Keratosis, Actinic
  7. (英) Keratosis, Seborrheic
  8. (英) Oncogenes
  9. (英) Point Mutation
  10. (英) Receptor, Fibroblast Growth Factor, Type 3
  11. (英) Skin Aging
  12. (英) Skin Neoplasms
  13. (英) Transcriptional Activation
発行所 推奨
誌名 必須 The British Journal of Dermatology(British Association of Dermatologists)
(pISSN: 0007-0963, eISSN: 1365-2133)
ISSN 任意 1365-2133
ISSN: 0007-0963 (pISSN: 0007-0963, eISSN: 1365-2133)
Title: The British journal of dermatology
Title(ISO): Br J Dermatol
Supplier: British Association of Dermatologists
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 160
必須 6
必須 1258 1263
都市 任意
年月日 必須 2009年 3月 9日
URL 任意
DOI 任意 10.1111/j.1365-2133.2009.09068.x    (→Scopusで検索)
PMID 任意 19298285    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't