著作: Nagao Tamiko/Hatcho Kazuki/Doi Naoya/Fujiwara Sachi/[足立 昭夫]/[野間口 雅子]/Amino acid alterations in Gag that confer the ability to grow in simian cells on HIV-1 are located at a narrow CA region./[The Journal of Medical Investigation : JMI]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Amino acid alterations in Gag that confer the ability to grow in simian cells on HIV-1 are located at a narrow CA region. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) We previously generated a prototype monkey-tropic human immunodeficiency virus type 1 (HIV-1) designated NL-DT5R. This viral clone has a small region of simian immunodeficiency virus (SIV) within Gag capsid (CA) protein and also SIV Vif protein, but displays a poor growth phenotype in simian cells. To improve the growth potential of NL-DT5R, we have constructed a series of its gag variant viruses. Out of fourteen viral clones generated, five were infectious for simian HSC-F cells, and two of the infectious variants grew similarly with NL-DT5R. Taking their genome structures into consideration, our data here clearly show that a narrow CA region within the Gag protein, i.e., the domain around cyclophilin A (CypA)-binding loop, is critical for the growth ability of HIV-1 in simian cells. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
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巻 | 必須 | 56 | |||
号 | 必須 | 1-2 | |||
頁 | 必須 | 21 25 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2009年 2月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.2152/jmi.56.21 (→Scopusで検索) | |||
PMID | 任意 | 19262010 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | ||||
機関リポジトリ | 110880 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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