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著作: [岩佐 武]/[松崎 利也]/Murakami Masahiro/Kinouchi Riyo/Ogata Rie/[桑原 章]/[安井 敏之]/[苛原 稔]/Neonatal lipopolysaccharide exposure attenuates the homotypic stress-induced suppression of LH secretion in adulthood in male rat./[International Journal of Developmental Neuroscience]

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EID
209101
EOID
654210
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LastModified
2012年8月28日(火) 21:34:32
Operator
大家 隆弘
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松崎 利也
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 岩佐 武([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 松崎 利也
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Murakami Masahiro
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    貢献度 任意
    学籍番号 推奨
  4. (英) Kinouchi Riyo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Ogata Rie
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 桑原 章
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 安井 敏之([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.生殖・更年期医療学]/[徳島大学.医学部.保健学科.看護学専攻.母性·小児看護学講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 苛原 稔
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Neonatal lipopolysaccharide exposure attenuates the homotypic stress-induced suppression of LH secretion in adulthood in male rat.

副題 任意
要約 任意

(英) Neonatal immune challenges have a long-lasting influence on immune response. Using male Sprague-Dawley rats, we examined whether neonatal lipopolysaccharide (LPS) challenge alters the sensitivity of male reproductive function to adult LPS challenge and at which level (central or testes) the alteration occurs. We also examined the mRNA expression of proinflammatory cytokines in the hypothalamus and testes because they have a pivotal role in immune stress-induced suppression of gonadotropin secretion and testosterone synthesis. On day 10 after birth, all the pups were injected with LPS (100 microg/kg, i.p.) or saline. Thereafter, LPS (100 microg/kg, i.p.) or saline was injected in adulthood at 8 weeks of age. The serum LH concentration was decreased by LPS injection during adulthood in the neonatal saline-injected rats. This suppressive effect was not seen in the neonatal LPS-injected rats. The serum testosterone concentration was decreased by adult LPS injection in both the neonatal LPS-injected and neonatal saline-injected rats. The expression levels of KiSS-1, which encodes kisspeptin, known to have a crucial role in the regulation of gonadotropin secretion, and GnRH mRNA in the hypothalamus and LHbeta mRNA in the pituitary were not influenced by neonatal or adult LPS injection. On the other hand, the expression levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA in the hypothalamus and testes were increased by adult LPS injection in both the neonatal LPS-injected and neonatal saline-injected rats. Furthermore, the expression levels of these factors in the hypothalamus after adult LPS injection were significantly lower in the neonatal LPS-injected rats than in the neonatal saline-injected rats. These findings indicate that neonatal LPS challenge reduces the sensitivity of male reproductive function to the suppressive effects of LPS, mainly at the central level. Attenuation of proinflammatory cytokine synthesis in the hypothalamus might be involved in this alteration.

キーワード 推奨
  1. (英) Animals
  2. (英) Animals, Newborn
  3. (英) Female
  4. 視床下部(hypothalamus)
  5. (英) Interleukin-1beta
  6. (英) Lipopolysaccharides
  7. (英) Luteinizing Hormone
  8. (英) Male
  9. 下垂体(pituitary gland)
  10. (英) Pregnancy
  11. (英) Rats
  12. (英) Rats, Sprague-Dawley
  13. (英) Stress, Physiological
  14. (英) Testis
  15. (英) Testosterone
  16. (英) Tumor Necrosis Factor-alpha
発行所 推奨
誌名 必須 International Journal of Developmental Neuroscience(International Society for Developmental Neuroscience)
(pISSN: 0736-5748, eISSN: 1873-474X)
ISSN 任意 1873-474X
ISSN: 0736-5748 (pISSN: 0736-5748, eISSN: 1873-474X)
Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Title(ISO): Int J Dev Neurosci
Supplier: International Society for Development Neuroscience
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 27
必須 4
必須 345 349
都市 任意
年月日 必須 2009年 3月 14日
URL 任意
DOI 任意 10.1016/j.ijdevneu.2009.03.004    (→Scopusで検索)
PMID 任意 19460628    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. takeshi1@clin.med.tokushima-u.ac.jp

  2. (英) PublicationType: Journal Article