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著作: Wang Elaine Lu/[銭 志栄]/Nakasono Masahiko/[棚橋 俊仁]/[吉本 勝彦]/[坂東 良美]/[工藤 英治]/[島田 光生]/[佐野 壽昭]/High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer./[British Journal of Cancer]

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EID
207481
EOID
974983
Map
0
LastModified
2020年3月19日(木) 20:07:36
Operator
吉本 勝彦
Avail
TRUE
Censor
0
Owner
吉本 勝彦
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Wang Elaine Lu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 銭 志栄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Nakasono Masahiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 棚橋 俊仁
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 吉本 勝彦
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 坂東 良美([徳島大学.病院.中央診療施設等.病理部])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 工藤 英治
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 島田 光生([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 佐野 壽昭
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer.

副題 任意
要約 任意

(英) BACKGROUND: The Toll-like receptor (TLR) 4 signalling pathway has been shown to have oncogenic effects in vitro and in vivo. To demonstrate the role of TLR4 signalling in colon tumourigenesis, we examined the expression of TLR4 and myeloid differentiation factor 88 (MyD88) in colorectal cancer (CRC). METHODS: The expression of TLR4 and MyD88 in 108 CRC samples, 15 adenomas, and 15 normal mucosae was evaluated by immunohistochemistry, and the correlations between their immunoscores and clinicopathological variables, including disease-free survival (DFS) and overall survival (OS), were analysed. RESULTS: Compared with normal mucosae and adenomas, 20% cancers displayed high expression of TLR4, and 23% cancers showed high expression of MyD88. The high expression of TLR4 and MyD88 was significantly correlated with liver metastasis (P=0.0001, P=0.0054). In univariate analysis, the high expression of TLR4 was significantly associated with shorter OS (hazard ratio (HR): 2.17; 95% confidence interval (95% CI): 1.15-4.07; P=0.015). The high expression of MyD88 expression was significantly associated with poor DFS and OS (HR: 2.33; 95% CI: 1.31-4.13; P=0.0038 and HR: 3.03; 95% CI: 1.67-5.48; P=0.0002). The high combined expression of TLR4 and MyD88 was also significantly associated with poor DFS and OS (HR: 2.25; 95% CI: 1.27-3.99; P=0.0053 and HR: 2.97; 95% CI: 1.64-5.38; P=0.0003). Multivariate analysis showed that high expressions of TLR4 (OS: adjusted HR: 1.88; 95% CI: 0.99-3.55; P=0.0298) and MyD88 (DFS: adjusted HR: 1.93; 95% CI: 1.01-3.67; P=0.0441; OS: adjusted HR: 2.25; 95% CI: 1.17-4.33; P=0.0112) were independent prognostic factors of OS. Furthermore, high co-expression of TLR4/MyD88 was strongly associated with both poor DFS and OS. CONCLUSION: Our findings suggest that high expression of TLR4 and MyD88 is associated with liver metastasis and is an independent predictor of poor prognosis in patients with CRC.

キーワード 推奨
  1. (英) Adenocarcinoma, Mucinous
  2. (英) Aged
  3. (英) Colon
  4. (英) Colorectal Neoplasms
  5. 女性(female)
  6. (英) Follow-Up Studies
  7. (英) Humans
  8. (英) Immunoenzyme Techniques
  9. (英) Liver Neoplasms
  10. 男性(male)
  11. (英) Myeloid Differentiation Factor 88
  12. (英) Neoplasm Invasiveness
  13. (英) Neoplasm Recurrence, Local
  14. (英) Peritoneal Neoplasms
  15. (英) Prognosis
  16. (英) Rectum
  17. (英) Survival Rate
  18. (英) Toll-Like Receptor 4
  19. (英) Tumor Markers, Biological
発行所 推奨
誌名 必須 British Journal of Cancer(British Empire Cancer Campaign/Cancer Research UK)
(pISSN: 0007-0920, eISSN: 1532-1827)
ISSN 任意 1532-1827
ISSN: 0007-0920 (pISSN: 0007-0920, eISSN: 1532-1827)
Title: British journal of cancer
Title(ISO): Br J Cancer
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 102
必須 5
必須 908 915
都市 任意
年月日 必須 2010年 2月 9日
URL 任意
DOI 任意 10.1038/sj.bjc.6605558    (→Scopusで検索)
PMID 任意 20145615    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-77649272127
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Human Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Japan.

  2. (英) PublicationType: Journal Article

  3. (英) PublicationType: Research Support, Non-U.S. Gov't