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著作: Nakata Kazuko/[吉丸 哲郎]/Suzuki Yoshihiro/Inoue Toshio/Ra Chisei/Yakura Hidetaka/Mizuno Kazuya/Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1./[The Journal of Immunology]

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EID
207363
EOID
721865
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0
LastModified
2014年2月1日(土) 19:51:56
Operator
大家 隆弘
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Owner
吉丸 哲郎
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Nakata Kazuko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 吉丸 哲郎([徳島大学.先端酵素学研究所.重点研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Suzuki Yoshihiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Inoue Toshio
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Ra Chisei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Yakura Hidetaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Mizuno Kazuya
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1.

副題 任意
要約 任意

(英) Src homology region 2 domain-containing phosphatase 1 (SHP-1), a cytoplasmic protein tyrosine phosphatase, plays an important role for the regulation of signaling from various hematopoietic cell receptors. Although SHP-1 is shown to be a negative signal modulator in mast cells, its precise molecular mechanisms are not well defined. To elucidate how SHP-1 regulates mast cell signaling, we established bone marrow-derived mast cells from SHP-1-deficient motheaten and wild-type mice and analyzed downstream signals induced by cross-linking of high affinity IgE receptor, Fc epsilonRI. Upon Fc epsilonRI ligation, motheaten-derived bone marrow-derived mast cells showed enhanced tyrosine phosphorylation of Src homology region 2 domain-containing leukocyte protein of 76 kDa (SLP-76) and linker for activation of T cells, activation of mitogen-activated protein kinases and gene transcription and production of cytokine. Because the activity of Syk, responsible for the phosphorylation of SLP-76 and linker for activation of T cells, is comparable irrespective of SHP-1, both molecules might be substrates of SHP-1 in mast cells. Interestingly, the absence of SHP-1 expression disrupted the association between SLP-76 and phospholipase Cgamma, which resulted in the decreased phospholipase Cgamma phosphorylation, calcium mobilization, and degranulation. Collectively, these results suggest that SHP-1 regulates Fc epsilonRI-induced downstream signaling events both negatively and positively by functioning as a protein tyrosine phosphatase and as an adaptor protein contributing to the formation of signaling complex, respectively.

キーワード 推奨
  1. (英) Adaptor Proteins, Signal Transducing
  2. (英) Animals
  3. (英) Calcium
  4. (英) Cell Degranulation
  5. (英) Extracellular Signal-Regulated MAP Kinases
  6. (英) Gene Expression Regulation, Enzymologic
  7. (英) Intracellular Signaling Peptides and Proteins
  8. (英) Lymphocyte Activation
  9. (英) Mast Cells
  10. (英) Mice
  11. (英) Mice, Mutant Strains
  12. (英) Phospholipase C gamma
  13. (英) Phosphoproteins
  14. (英) Phosphorylation
  15. (英) Protein Tyrosine Phosphatase, Non-Receptor Type 6
  16. (英) Protein-Tyrosine Kinases
  17. (英) Receptors, IgE
  18. (英) Signal Transduction
  19. (英) T-Lymphocytes
発行所 推奨
誌名 必須 The Journal of Immunology([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
ISSN 任意 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 181
必須 8
必須 5414 5424
都市 任意
年月日 必須 2008年 10月 15日
URL 任意
DOI 任意
PMID 任意 18832698    (→Scopusで検索)
NAID 任意
WOS 任意 000260025300033
Scopus 任意 2-s2.0-54049146268
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Immunology and Signal Transduction, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Science, Fuchu, Tokyo, Japan.

  2. (英) PublicationType: Journal Article