徳島大学 教育・研究者情報データベース(EDB)

1. 林 良夫

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2. 新垣 理恵子

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3. 石丸 直澄([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])

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(英) Salivary gland and autoimmunity

(英) Recent evidences suggest that the apoptotic pathway plays a central role in tolerazing T cells to tissue-specific self antigen, and may drive the autoimmune phenomenon in the salivary glands. We found that retinoblastoma-associated protein RbAp48 overexpression induces p53-mediated apoptosis in the salivary glands caused by estrogen deficiency. We demonstrated that transgenic (Tg) expression of RbAp48 resulted in the development of autoimmune exocrinopathy resembling Sjögren's syndrome (SS). CD4(+)T cell-mediated autoimmune lesions in the salivary glands were aggravated with age, in association with autoantibody productions. We obtained evidences that salivary epithelial cells can produce interferon-gamma (IFN-gamma) besides interleukin (IL)-18, which activates interferon regulatory factor-1 (IRF-1), and class II transactivator (CIITA). Indeed, the autoimmune lesions into Rag2(-/-) mice were induced by the adoptive transfer of lymph node cells from RbAp48-Tg mice. These results indicate a novel immunocompetent role of epithelial cells that can produce IFN-gamma, resulting in loss of local tolerance prior to developing gender-based autoimmunity. The studies reviewed the molecular mechanisms on the development of salivary gland autoimmunity, and gender-related differences in SS.

1. (英) Animals
2. (英) Apoptosis
3. (英) Autoimmunity
4. (英) Disease Models, Animal
5. (英) Female
6. (英) Male
7. (英) Mice
8. (英) Mice, Transgenic
9. (英) Retinoblastoma-Binding Protein 4
10. (英) Salivary Glands
11. (英) Sex Characteristics
12. (英) Sjogren's Syndrome
13. (英) T-Lymphocytes

1. (英) Article.Affiliation: Department of Oral Molecular Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Lectures