徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院ソシオ・アーツ・アンド・サイエンス研究部.創生科学研究部門.環境共生科学分野(2009年4月1日〜2016年3月31日)
2. 徳島大学.総合科学部.社会創生学科.環境共生コース(2009年4月1日〜2024年3月31日)

1. (英) Nishimura Yumiko

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2. 小山 保夫

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(英) Cytotoxic actions of lidocaine at sublethal concentrations: A model in vitro experiment using rat thymocytes

(英) In order to reveal some cytotoxic features of lidocaine, the effects of lidocaine at sublethal concentrations (10 mM or less) on rat thymocytes were examined by the use of flow-cytometric technique with fluorescent probes. Treatment with lidocaine at 3-10 mM for 1-3 hr significantly increased intracellular Ca2+ and Zn2+ concentrations under normal condition. After the removal of external Ca2+ and Zn2+, lidocaine still increased intracellular Ca2+ and Zn2+ concentrations, suggesting the lidocaine-induced release of intracellular Ca2+ and Zn2+. Treatment with lidocaine at 0.3-1 mM for 24 hr significantly increased the populations of dead cells and shrunken cells. Lidocaine at sublethal concentrations exerts some cellular actions that are supposed to be linked to the cytotoxicity. The mechanism of lidocaine-induced cell death varies in time- and concentration-dependent manners.

1. 細胞毒性(cytotoxicity)