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著作: [中川 弘]/[樋浦 明夫]/[三留 雅人]/[石村 和敬]/Nerve fibers that were not stained with the non-specific acetylcholinesterase (NsAchE) method, and TRPV1- and IB4-positive nerve fibers in the rat cornea.(Cited in "Journal of Chemical Neuroanatomy, 01/2014")/[The Journal of Medical Investigation : JMI]

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EID
203921
EOID
907254
Map
0
LastModified
2018年5月23日(水) 17:08:14
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[ADMIN]
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Owner
中川 弘
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 中川 弘([徳島大学.病院.診療科.小児歯科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 樋浦 明夫
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 三留 雅人
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 石村 和敬
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Nerve fibers that were not stained with the non-specific acetylcholinesterase (NsAchE) method, and TRPV1- and IB4-positive nerve fibers in the rat cornea.(Cited in "Journal of Chemical Neuroanatomy, 01/2014")

副題 任意
要約 任意

(英) Previously, we noticed the presence of nerve fiber-like structures in a whole mount preparation of the rat cornea that had not been stained with the non-specific acetylcholinesterase (NsAchE) method. These nerve-like fibers were projected into the central area of the cornea, forming a mesh-like pattern. The aim of this study is to examine the properties of these mesh-like fibers using the following two methods: their sensitivity to capsaicin and the detection of isolectin B4 (IB4)- and capsaicin receptor TRPV1 (transient receptor potential vanilloid 1)-reactivities. The mean disappeared area of non-stained fibers after NsAchE treatment was 26% of the total areas in the neonatally capsaicin-treated cornea. Bunches composed of fine IB4-positive nerve fibers were seen in a whole mount preparation. There were connections between the bunches, producing a mesh-like pattern similar to that of the fibers that were not stained with NsAchE. Fine TRPV1-immunoreactive (ir) nerve fibers were also shown to form bunches, with connections between each bunch observed in whole mount preparations. Thus, TRPV1-ir nerve fibers seem to densely innervate the rat corneal subepithelial stroma and are distinct from the NsAchE-positive nerve fibers. The TRPV1-ir fine nerve fibers overlapped with the IB4-positive nerve fibers, suggesting that the mesh-like fibers that were not stained with NsAchE are fine nociceptive sensory nerve fibers because of their sensitivity to capsaicin and similar distribution pattern to IB4- and TRPV1-positive nerve fibers.

キーワード 推奨
  1. (英) TRPV1
  2. (英) IB4
  3. (英) Nociceptive sensory nerve fibers
  4. 角膜(cornea)
  5. カプサイシン(capsaicin)
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 56
必須 3,4
必須 157 165
都市 任意
年月日 必須 2009年 8月 末日
URL 任意
DOI 任意 10.2152/jmi.56.157    (→Scopusで検索)
PMID 任意 19763029    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
機関リポジトリ 111323
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Pediatric Dentistry, Tokushima University Hospital, Tokushima , Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article