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著作: Imamura, H./Takaishi, K./Nakano, K./Kodama, A./Oishi, H./Shiozaki, H./Monden, M./[佐々木 卓也]/Takai, Y./Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells./[Molecular Biology of the Cell]

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EID
201845
EOID
853291
Map
0
LastModified
2017年4月15日(土) 20:53:05
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
佐々木 卓也
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Imamura, H.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Takaishi, K.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Nakano, K.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kodama, A.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Oishi, H.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Shiozaki, H.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Monden, M.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 佐々木 卓也([徳島大学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Takai, Y.
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells.

副題 任意
要約 任意

(英) The Rho subfamily of the Rho small G protein family (Rho) regulates formation of stress fibers and focal adhesions in many types of cultured cells. In moving cells, dynamic and coordinate disassembly and reassembly of stress fibers and focal adhesions are observed, but the precise mechanisms in the regulation of these processes are poorly understood. We previously showed that 12-O-tetradecanoylphorbol-13-acetate (TPA) first induced disassembly of stress fibers and focal adhesions followed by their reassembly in MDCK cells. The reassembled stress fibers showed radial-like morphology that was apparently different from the original. We analyzed here the mechanisms of these TPA-induced processes. Rho inactivation and activation were necessary for the TPA-induced disassembly and reassembly, respectively, of stress fibers and focal adhesions. Both inactivation and activation of the Rac subfamily of the Rho family (Rac) inhibited the TPA-induced reassembly of stress fibers and focal adhesions but not their TPA-induced disassembly. Moreover, microinjection or transient expression of Rab GDI, a regulator of all the Rab small G protein family members, inhibited the TPA-induced reassembly of stress fibers and focal adhesions but not their TPA-induced disassembly, indicating that, furthermore, activation of some Rab family members is necessary for their TPA-induced reassembly. Of the Rab family members, at least Rab5 activation was necessary for the TPA-induced reassembly of stress fibers and focal adhesions. The TPA-induced, small G protein-mediated reorganization of stress fibers and focal adhesions was closely related to the TPA-induced cell motility. These results indicate that the Rho and Rab family members coordinately regulate the TPA-induced reorganization of stress fibers and focal adhesions that may cause cell motility.

キーワード 推奨
  1. (英) Actins
  2. (英) Animals
  3. (英) Cell Adhesion
  4. (英) Cell Line
  5. (英) Cytoskeleton
  6. (英) Dogs
  7. (英) GTP-Binding Proteins
  8. (英) Guanine Nucleotide Dissociation Inhibitors
  9. (英) Hepatocyte Growth Factor
  10. (英) Humans
  11. (英) Tetradecanoylphorbol Acetate
  12. (英) rab GTP-Binding Proteins
  13. (英) rab5 GTP-Binding Proteins
  14. (英) rac GTP-Binding Proteins
  15. (英) rhoA GTP-Binding Protein
発行所 推奨
誌名 必須 Molecular Biology of the Cell(The American Society for Cell Biology)
(pISSN: 1059-1524, eISSN: 1939-4586)
ISSN 任意 1059-1524
ISSN: 1059-1524 (pISSN: 1059-1524, eISSN: 1939-4586)
Title: Molecular biology of the cell
Title(ISO): Mol Biol Cell
Publisher: American Society for Cell Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 9
必須 9
必須 2561 2575
都市 任意
年月日 必須 1998年 9月 初日
URL 任意
DOI 任意 10.1091/mbc.9.9.2561    (→Scopusで検索)
PMID 任意 9725912    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  3. (英) OtherID: PMC25527