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著作: [中村 教泰]/[石村 和敬]/One-pot synthesis and characterization of three kinds of thiol-organosilica nanoparticles/[Langmuir]

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2018年2月13日(火) 12:01:28
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三木 ちひろ
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[副研究部長]/[徳島大学.大学院医歯薬学研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 中村 教泰
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 石村 和敬
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) One-pot synthesis and characterization of three kinds of thiol-organosilica nanoparticles

副題 任意
要約 任意

(英) Using a one-pot synthesis, thiol-organosilica nanoparticles (NPs) made from (3-mercaptopropyl)trimethoxysilane, (3-mercaptopropyl)triethoxysilane, and (3-mercaptopropyl)methyldimethoxysilane have been successfully prepared. We compared the synthesis processes of thiol-organosilica NPs made of these three kinds of organosilicates, as well as particles made from tetraethoxysilicate (TEOS), at concentrations varying between 6.25 and 200 mM. We examined three types of synthetic conditions: the Stöber method, in which particles are prepared in 65% ethanol, and two entirely aqueous solvent syntheses, containing either 2% or 27% ammonium hydroxide. The synthetic mixtures were examined using transmission electron microscopy (TEM) to evaluate the as-prepared NPs. The formation trends and rates for these organosilica NPs vary with differing organosilicate precursors, concentrations, and synthetic conditions. The Stöber method is not suitable for formation of thiol-organosilica NPs as compared with the case of TEOS, but the conditions without ethanol and with 27% ammonium hydroxide are suitable for the formation of thiol-organosilica NPs. The size distributions of the formed NPs were evaluated using TEM and dynamic light scattering. The mean diameters of NPs increase with increasing concentrations of silicate, but the size distributions of NPs prepared under various conditions also differ between silicate sources. Thiol-organosilica NPs internally functionalized with fluorescent dye were also prepared using a one-pot synthesis and were characterized using fluorescence microscopy. The thiol-organosilica NPs retain fluorescent dye maleimide very well. In addition, rhodamine B-doped thiol-organosilica NPs show higher fluorescence than thiol-organosilica NPs prepared with rhodamine red maleimide. The surface of thiol-organosilica NPs contains exposed thiol residues, allowing the covalent attachment of fluorescent dye maleimide and protein maleimide. This is the first report describing the synthesis of thiol-organosilica NPs made of three kinds of thiol-organosilicates, differences in nanoparticle formation due to the kinds and concentrations of thiol-organosilicate and due to synthetic conditions, and the advantages of thiol-organosilica NPs due to the existence of both interior and exterior thiol residues.

キーワード 推奨
  1. 透過電子顕微鏡法(transmission electron microscopy)
  2. ナノ粒子(nanoparticles/->キーワード[ナノ粒子])
  3. (英) Organosilicon Compounds
  4. (英) Particle Size
  5. (英) Sulfhydryl Compounds
  6. 界面特性(surface properties)
発行所 推奨
誌名 必須 Langmuir([アメリカ化学会])
(pISSN: 0743-7463, eISSN: 1520-5827)
ISSN 任意 0743-7463
ISSN: 0743-7463 (pISSN: 0743-7463, eISSN: 1520-5827)
Title: Langmuir : the ACS journal of surfaces and colloids
Title(ISO): Langmuir
Publisher: American Chemical Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 24
必須 9
必須 5099 5108
都市 任意
年月日 必須 2008年 3月 27日
URL 任意
DOI 任意 10.1021/la703395w    (→Scopusで検索)
PMID 任意 18366224    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-44249121760
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Anatomy and Cell Biology, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. michy@basic.med.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't