徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: [中村 教泰]/[石村 和敬]/Size-controlled, One-pot Synthesis, Characterization, and Biological Applications of Epoxy-Organosilica Particles Possessing Positive Zeta Potential as Prepared. Langmuir/[Langmuir]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
195146
EOID
887847
Map
0
LastModified
2018年2月13日(火) 13:52:22
Operator
三木 ちひろ
Avail
TRUE
Censor
0
Owner
[副研究部長]/[徳島大学.大学院医歯薬学研究部]
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 中村 教泰
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 石村 和敬
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Size-controlled, One-pot Synthesis, Characterization, and Biological Applications of Epoxy-Organosilica Particles Possessing Positive Zeta Potential as Prepared. Langmuir

副題 任意
要約 任意

(英) Epoxy-organosilica particles made from 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane (EpoMS) as a single silica source were synthesized by means of a one-pot method. We evaluated three sets of synthesis conditions, including traditional Stober conditions and two variations. Although the traditional conditions did not afford EpoMS particles, the variations did. The size distributions of the particles were evaluated by means of transmission electron microscopy. The mean diameters and size distributions of the particles depended on the EpoMS concentration, and the best coefficient of variation for the size distribution was 5.9%. The surface of the particles had unique properties, such as a positive zeta potential. The particles bound strongly to proteins as well as to DNA. The particles made from EpoMS, allowing particles internally functionalized with fluorescent dye to be prepared by means of a one-pot synthesis. EpoMS particles doped and tuned with fluorescent dye showed strong fluorescence signals and distinct peaks on flow cytometry, and the fluorescent particles could be used to label cells. The labeled cells showed clear fluorescence under a fluorescence microscope, and electron microscopy showed many particles in the cytoplasm. This is the first report describing the synthesis of epoxy-organosilica particles with a positive zeta potential and describing differences in the characteristics of particle formations due to changes in synthesis conditions. We also discuss the advantages of EpoMS particles, as well as the potential biological applications of these particles.

キーワード 推奨
  1. (英) Animals
  2. (英) Base Sequence
  3. (英) Epoxy Compounds
  4. (英) Flow Cytometry
  5. (英) Male
    データベース中に適合する可能性のある以下の情報を発見しました
    [キーワード] 女性 (female)
    [キーワード] 男性 (male)
  6. (英) Mice
    データベース中に適合する可能性のある以下の情報を発見しました
    [キーワード] ノックアウトマウス (knockout mice)
  7. (英) Mice, Inbred C57BL
  8. 透過電子顕微鏡法(transmission electron microscopy)
  9. (英) Microscopy, Fluorescence
  10. (英) Oligonucleotides
  11. (英) Silicon Dioxide
発行所 推奨
誌名 必須 Langmuir([アメリカ化学会])
(pISSN: 0743-7463, eISSN: 1520-5827)
ISSN 任意 0743-7463
ISSN: 0743-7463 (pISSN: 0743-7463, eISSN: 1520-5827)
Title: Langmuir : the ACS journal of surfaces and colloids
Title(ISO): Langmuir
Publisher: American Chemical Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 24
必須 21
必須 12228 12234
都市 任意
年月日 必須 2008年 9月 30日
URL 任意
DOI 任意 10.1021/la801950q    (→Scopusで検索)
PMID 任意 18823130    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-56449102553
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Anatomy and Cell Biology, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. michy@basic.med.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't