193840: Nishimoto Kazumasa/Kochi Yuta/Ikari Katsunori/Yamamoto Kazuhiko/Suzuki Akari/Shimane Kenichi/Nakamura Yusuke/Yano Koichiro/Iikuni Noriko/Tsukahara So/[鎌谷直之]/Okamoto Hiroshi/Kaneko Hirotaka/Kawaguchi Yasushi/Hara Masako/Toyama Yoshiaki/Horiuchi Takahiko/Tao Kayoko/[安友康二]/[浜田大輔]/[安井夏生]/[井上寛]/[板倉光夫]/Yamanaka Hisashi/Momohara Shigeki/Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese./[Annals of the Rheumatic Diseases]

著作: Nishimoto Kazumasa/Kochi Yuta/Ikari Katsunori/Yamamoto Kazuhiko/Suzuki Akari/Shimane Kenichi/Nakamura Yusuke/Yano Koichiro/Iikuni Noriko/Tsukahara So/[鎌谷直之]/Okamoto Hiroshi/Kaneko Hirotaka/Kawaguchi Yasushi/Hara Masako/Toyama Yoshiaki/Horiuchi Takahiko/Tao Kayoko/[安友康二]/[浜田大輔]/[安井夏生]/[井上寛]/[板倉光夫]/Yamanaka Hisashi/Momohara Shigeki/Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese./[Annals of the Rheumatic Diseases]

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EID: 193840
EOID: 660970
Map: 0
LastModified: 2012年9月19日(水) 12:09:10
Operator: 三木ちひろ
Avail: TRUE
Censor: 0
Owner: 安井夏生
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

著者

必須

(英) Nishimoto Kazumasa

役割任意

貢献度任意

学籍番号推奨
(英) Kochi Yuta

役割任意

貢献度任意

学籍番号推奨
(英) Ikari Katsunori

役割任意

貢献度任意

学籍番号推奨
(英) Yamamoto Kazuhiko

役割任意

貢献度任意

学籍番号推奨
(英) Suzuki Akari

役割任意

貢献度任意

学籍番号推奨
(英) Shimane Kenichi

役割任意

貢献度任意

学籍番号推奨
(英) Nakamura Yusuke

役割任意

貢献度任意

学籍番号推奨
(英) Yano Koichiro

役割任意

貢献度任意

学籍番号推奨
(英) Iikuni Noriko

役割任意

貢献度任意

学籍番号推奨
(英) Tsukahara So

役割任意

貢献度任意

学籍番号推奨
鎌谷直之([徳島大学.ゲノム機能研究センター])

役割任意

貢献度任意

学籍番号推奨
(英) Okamoto Hiroshi

役割任意

貢献度任意

学籍番号推奨
(英) Kaneko Hirotaka

役割任意

貢献度任意

学籍番号推奨
(英) Kawaguchi Yasushi

役割任意

貢献度任意

学籍番号推奨
(英) Hara Masako

役割任意

貢献度任意

学籍番号推奨
(英) Toyama Yoshiaki

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貢献度任意

学籍番号推奨
(英) Horiuchi Takahiko

役割任意

貢献度任意

学籍番号推奨
(英) Tao Kayoko

役割任意

貢献度任意

学籍番号推奨
安友康二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])

役割任意

貢献度任意

学籍番号推奨
浜田大輔([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.運動機能外科学]/[徳島大学.病院.診療科.感覚·皮膚·運動機能科.整形外科])

役割任意

貢献度任意

学籍番号推奨
安井夏生

役割任意

貢献度任意

学籍番号推奨
井上寛

役割任意

貢献度任意

学籍番号推奨
板倉光夫

役割任意

貢献度任意

学籍番号推奨
(英) Yamanaka Hisashi

役割任意

貢献度任意

学籍番号推奨
(英) Momohara Shigeki

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese.

副題

任意

要約

任意

(英) The primary aim of this study was to investigate the association of polymorphisms of TRAF1-C5, a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility to RA and systemic lupus erythematosus (SLE) in Japanese populations. Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed. A multicentre association study consisting of 4 RA case-control series (4397 cases and 2857 controls) and 3 SLE case-control series (591 cases and 2199 shared controls) was conducted. Genotyping was performed using TaqMan genotyping assay for two single nucleotide polymorphisms (SNPs) that showed the best evidence of association in the previous Caucasian studies. Quantifications of TRAF1 and C5 expression were performed with TaqMan expression assay. Significant differences in allele frequency for both SNPs were observed between RA and control subjects (combined odds ratio = 1.09), while no significant difference was detected between patients with SLE and controls. Interestingly, alleles rs3761847 A and rs10818488 G had increased the risk for RA in the present study, while they decreased the risk in the original studies. A significant difference was found between risk allele carriers and non-carriers of rs10818488 for the expression level of TRAF1 in phorbol myristate acetate-stimulated lymphoblastoid cell lines (p = 0.04). Association of TRAF1-C5 locus with RA susceptibility was detected in the Japanese populations with modest magnitude, while no significant association was observed for SLE. Significant positive effect of genotype on the expression of TRAF1 might support the genetic association between TRAF1 and RA.

キーワード

推奨

(英) Arthritis, Rheumatoid
(英) Asian Continental Ancestry Group
(英) Autoantibodies
(英) Case-Control Studies
(英) Cell Line
(英) Complement C5
(英) Female
(英) Genetic Predisposition to Disease
(英) Genome-Wide Association Study
(英) Genotype
(英) Hand Joints
(英) Humans
(英) Lupus Erythematosus, Systemic
(英) Male
(英) Middle Aged
(英) Polymorphism, Single Nucleotide
(英) TNF Receptor-Associated Factor 1

発行所

推奨

誌名

必須

Annals of the Rheumatic Diseases(Empire Rheumatism Council/British Medical Association)

(pISSN: 0003-4967, eISSN: 1468-2060)

ISSN	任意	1468-2060 ISSN: 0003-4967 (pISSN: 0003-4967, eISSN: 1468-2060) Title: Annals of the rheumatic diseases Title(ISO): Ann Rheum Dis Publisher: BMJ Group (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

号

必須

頁

必須

368 373

都市

任意

年月日

必須

2009年 3月 30日

URL

任意

DOI

任意

10.1136/ard.2008.104315 (→Scopusで検索)

PMID

任意

19336421 (→Scopusで検索)

CRID

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WOS

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Scopus

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評価値

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被引用数

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指導教員

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備考

任意

(英) Article.Affiliation: Institute of Rheumatology, Tokyo Women's Medical University, Japan.
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Multicenter Study
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

徳島大学教育・研究者情報データベース(EDB)

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