徳島大学 教育・研究者情報データベース(EDB)

1. 石丸 直澄

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2. (英) Atuya Takagi

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3. (英) Masayuki Kohashi

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4. 山田 安希子

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5. 新垣 理恵子

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6. (英) Jun Kanno

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7. 林 良夫

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(英) Neonatal Exposure to Loe-Dose 2.3.7.8-Tetrachlorodibenzo-p-Dioxin Causes Autoimmunity Due to the Disruption of TCell Tolerance1

(英) Although 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been shown to influence immune responses, the effects of low-dose TCDD on the development of autoimmunity are unclear. In this study, using NFS/sld mice as a model for human Sjögren's syndrome, in which the lesions are induced by the thymectomy on day 3 after birth, the autoimmune lesions in the salivary glands, and in later phase, inflammatory cell infiltrations in the other organs were developed by neonatal exposure to nonapoptotic dosage of TCDD without thymectomy on day 3 after birth. We found disruption of thymic selection, but not thymic atrophy, in TCDD-administered mice. The endogenous expression of aryl hydrocarbon receptor in the neonatal thymus was significantly higher than that in the adult thymus, suggesting that the neonatal thymus may be much more sensitive to TCDD compared with the adult thymus. In addition, the production of T(H)1 cytokines such as IL-2 and IFN-gamma from splenic CD4(+) T cells and the autoantibodies relevant for Sjögren's syndrome in the sera from TCDD-exposed mice were significantly increased compared with those in control mice. These results suggest that TCDD/aryl hydrocarbon receptor signaling in the neonatal thymus plays an important role in the early thymic differentiation related to autoimmunity.

1. (英) Animals
2. (英) Animals, Newborn
3. (英) Autoantigens
4. 自己免疫(autoimmunity)
5. (英) Cell Proliferation
6. 細胞質分裂(cytokinesis)
7. (英) Disease Models, Animal
8. 環境汚染物質(Environmental pollutants)
9. (英) Enzyme-Linked Immunosorbent Assay
10. (英) Flow Cytometry
11. (英) Immune Tolerance
12. (英) Mice
13. (英) Mice, Mutant Strains
14. (英) Microscopy, Confocal
15. (英) Receptors, Aryl Hydrocarbon
16. (英) Reverse Transcriptase Polymerase Chain Reaction
17. 情報伝達(signal transduction/->キーワード[シグナル伝達])
18. シェーグレン症候群(Sjögren's syndrome)
19. Tリンパ球(T lymphocytes)
20. (英) Tetrachlorodibenzodioxin
21. (英) Thymus Gland

1. (英) Article.Affiliation: Department of Oral Molecular Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramotocho, Tokushima, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't