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著作: Hisaeda H/Nagasawa H/Maeda K/[前川 洋一]/Ishikawa H/Ito Y/Good A. R/Himeno K/Gamma delta T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii./[The Journal of Immunology]

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EID
193209
EOID
667674
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LastModified
2012年10月26日(金) 11:22:40
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三木 ちひろ
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[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須
言語 必須 英語
招待 推奨
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著者 必須
  1. (英) Hisaeda H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Nagasawa H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Maeda K
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    貢献度 任意
    学籍番号 推奨
  4. 前川 洋一
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    学籍番号 推奨
  5. (英) Ishikawa H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Ito Y
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Good A. R
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  8. (英) Himeno K
    役割 任意
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題名 必須

(英) Gamma delta T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii.

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(英) Previously, we reported that the expression of hsp65 within and on host macrophages correlates closely with protection against infection with Toxoplasma gondii in mice. Herein, we propose that gamma delta T cells play a crucial role in the induction of hsp65 and also in the protective immune response to T. gondii. Intraperitoneal inoculation with this protozoan resulted in hsp65 being expressed on and in host peritoneal macrophages and resulted in an increase of T cells bearing the gamma delta receptor with Thy-1+ and Thy-1- phenotypes in the peritoneal cavity and spleen. When mice were depleted of gamma delta T cells by the administration of a mAb, hsp65 expression was markedly decreased. In contrast, the expression of this protein was rather enhanced and gamma delta T cells were prominently expanded in mice depleted of alpha beta T cells. The protection in mice treated with the mAb paralleled the magnitude of hsp65 expression. Mice depleted of gamma delta T cells died most frequently in the early stages of infection, whereas most of those depleted of alpha beta T cells survived the early stages of lethal infection with T. gondii. However, the latter group of mice did not definitely control the T. gondii infection in its late stages. IFN-gamma was not essential for either the expression of hsp65 or the resistance induced by gamma delta T cells, as demonstrated in mice treated with mAb to murine IFN-gamma. These findings indicated that gamma delta T cells having both the Thy-1+ and Thy-1- phenotypes contribute to hsp65 expression within and on macrophages in an IFN-gamma-independent manner. This, in turn, plays a role in the development of protective immunity during the early stage of this parasitic infection.

キーワード 推奨
  1. (英) Animals
  2. (英) Bacterial Proteins
  3. (英) Blotting, Western
  4. (英) Chaperonins
  5. (英) Female
  6. (英) Flow Cytometry
  7. (英) Immunization, Passive
  8. 免疫組織化学(immunohistochemistry)
  9. (英) Interferon-gamma
  10. (英) Lymphocyte Depletion
  11. (英) Mice
  12. (英) Mice, Inbred BALB C
  13. (英) Microscopy, Immunoelectron
  14. (英) Receptors, Antigen, T-Cell, gamma-delta
  15. Tリンパ球(T lymphocytes)
  16. (英) Toxoplasma
  17. (英) Toxoplasmosis, Animal
発行所 推奨
誌名 必須 The Journal of Immunology([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
ISSN 任意 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 155
必須 1
必須 244 251
都市 任意
年月日 必須 1995年 7月 1日
URL 任意
DOI 任意
PMID 任意 7602101    (→Scopusで検索)
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  1. (英) Article.Affiliation: Department of Parasitology and Immunology, University of Tokushima, School of Medicine, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.