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著作: Hisaeda H/Sakai T/Nagasawa H/Ishikawa H/Yasutomo K/[前川 洋一]/Himeno K/Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii./[Immunology]

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EID
193202
EOID
667681
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LastModified
2012年10月26日(金) 11:22:40
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三木 ちひろ
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[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須
言語 必須 英語
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著者 必須
  1. (英) Hisaeda H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Sakai T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Nagasawa H
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    貢献度 任意
    学籍番号 推奨
  4. (英) Ishikawa H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Yasutomo K
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 前川 洋一
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Himeno K
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii.

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(英) We demonstrated that gamma delta T cells contribute to protective immunity against Toxoplasma gondii by inducing the expression of a 65,000 MW heat-shock protein (hsp 65) in host macrophages. Here we examined the role of extrathymic and intrathymic gamma delta T cells in protective immunity and hsp 65 expression in mice infected with T. gondii. Intrathymic gamma delta T cells were obtained from severe combined immunodeficiency (SCID) mice grafted with syngeneic fetal thymus (TG-SCID), in which only T cells derived from the donor thymus developed, whereas extrathymic gamma delta T cells were obtained from nude mice that lack thymus. Extrathymic gamma delta T cells from T. gondii-infected nude mice differed from intrathymic gamma delta T cells of infected TG-SCID mice, in terms of Thy1.2 expression and V-region gene usage of T-cell receptor (TCR) gamma delta. Extrathymic gamma delta T cells expressed extremely high levels of Thy1.2, and had V gamma 7 repertoire but lacked V gamma 5,6 and V delta 1,5. On the other hand, intrathymic gamma delta T cells express intermediate and low levels of Thy1,2. These cells possessed V gamma 5,6 and V delta 1,5 but failed to rearrange the V gamma 7 gene. Peritoneal macrophages from infected nude mice contained hsp 65, whereas this protein was scarcely expressed in those of infected TG-SCID mice. Transfer of extrathymic, but not of intrathymic gamma delta T cells to SCID mice enabled their macrophages to express hsp 65. Athymic nude mice were significantly resistant to the infection compared with SCID mice which lack gamma delta T as well as alpha beta T cells. The resistance was dependent upon extrathymic gamma delta T cells, since nude mice depleted of gamma delta T cells using a corresponding monoclonal antibody became extremely susceptible. These results indicated that extrathymic rather than intrathymic gamma delta T cells play some crucial roles in protection against T. gondii and in hsp 65 expression.

キーワード 推奨
  1. (英) Animals
  2. (英) Bacterial Proteins
  3. (英) Base Sequence
  4. (英) Blotting, Western
  5. (英) Chaperonins
  6. (英) Macrophages, Peritoneal
  7. (英) Mice
  8. (英) Mice, Inbred BALB C
  9. (英) Mice, Inbred Strains
  10. (英) Mice, Nude
  11. (英) Molecular Sequence Data
  12. (英) Peritoneal Cavity
  13. (英) Polymerase Chain Reaction
  14. (英) Receptors, Antigen, T-Cell, gamma-delta
  15. (英) T-Lymphocyte Subsets
  16. (英) Toxoplasmosis, Animal
発行所 推奨
誌名 必須 Immunology(British Society for Immunology)
(pISSN: 0019-2805, eISSN: 1365-2567)
ISSN 任意 0019-2805
ISSN: 0019-2805 (pISSN: 0019-2805, eISSN: 1365-2567)
Title: Immunology
Title(ISO): Immunology
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 88
必須 4
必須 551 557
都市 任意
年月日 必須 1996年 8月 初日
URL 任意
DOI 任意
PMID 任意 8881756    (→Scopusで検索)
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  1. (英) Article.Affiliation: Department of Parasitology and Immunology, University of Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) OtherID: PMC1456633