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著作: Hisaeda H/Sakai T/Ishikawa H/[前川 洋一]/Yasutomo K/Good A. R/Himeno K/Heat shock protein 65 induced by gammadelta T cells prevents apoptosis of macrophages and contributes to host defense in mice infected with Toxoplasma gondii./[The Journal of Immunology]

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EID
193200
EOID
667683
Map
0
LastModified
2012年10月26日(金) 11:22:40
Operator
三木 ちひろ
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TRUE
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Owner
[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
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著者 必須
  1. (英) Hisaeda H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Sakai T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Ishikawa H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 前川 洋一
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Yasutomo K
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Good A. R
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Himeno K
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Heat shock protein 65 induced by gammadelta T cells prevents apoptosis of macrophages and contributes to host defense in mice infected with Toxoplasma gondii.

副題 任意
要約 任意

(英) We previously reported that gammadelta T cells mediate the expression of endogenous heat shock protein 65 (HSP65) in macrophages of mice with acquired resistance against infection with Toxoplasma gondii. We show here that HSP65 contributes to protective immunity by preventing apoptosis of infected macrophages. Macrophages of BALB/c mice, which readily acquired resistance to T. gondii infection with the low virulence Beverley strain, strongly expressed HSP65, and only a few of these macrophages underwent apoptosis. On the other hand, the BALB/c mice were susceptible to the infection with the high virulence RH strain of T. gondii; their macrophages did not express HSP65 and did undergo apoptosis. Mice depleted of gammadelta T cells using a mAb specific for TCR-gammadelta became highly susceptible to infection even with the Beverley strain. In these mice, HSP65 expression was markedly suppressed, and their infected macrophages died via apoptosis. Apoptosis was induced in cultured macrophages or macrophage cell lines after infection in vitro with the RH strain, whereas apoptosis was prevented when HSP65 was induced in these cells, before infection, by activation with IFN-gamma and TNF-alpha. However, apoptosis associated with infection by T. gondii RH strain was not prevented when HSP65 synthesis was inhibited by introducing an antisense oligonucleotide for this protein into the cells before activation with IFN-gamma plus TNF-alpha. Thus, HSP65 appears to contribute to immunity by preventing the apoptosis of infected macrophages, and the high virulence Toxoplasma appears to have mechanisms that allow these organisms to evade the host defense system by interfering with HSP65 expression.

キーワード 推奨
  1. (英) Animals
  2. (英) Antibodies, Monoclonal
  3. (英) Apoptosis
  4. (英) Bacterial Proteins
  5. (英) Cells, Cultured
  6. (英) Chaperonins
  7. (英) Disease Susceptibility
  8. (英) Female
  9. (英) Gene Expression Regulation
  10. (英) Host-Parasite Interactions
  11. (英) Immunization
  12. (英) Macrophages, Peritoneal
  13. (英) Mice
  14. (英) Mice, Inbred BALB C
  15. (英) Oligonucleotides, Antisense
  16. (英) Proto-Oncogene Proteins c-bcl-2
  17. (英) Receptors, Antigen, T-Cell, gamma-delta
  18. (英) Toxoplasma
  19. (英) Toxoplasmosis, Animal
  20. (英) Tumor Cells, Cultured
  21. (英) Virulence
発行所 推奨
誌名 必須 The Journal of Immunology([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
ISSN 任意 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 159
必須 5
必須 2375 2381
都市 任意
年月日 必須 1997年 9月 1日
URL 任意
DOI 任意
PMID 任意 9278328    (→Scopusで検索)
NAID 任意
WOS 任意
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評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Parasitology and Immunology, The University of Tokushima School of Medicine, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.