192649: Honda Junko/Sasa Mitsunori/Moriya Takuya/[坂東良美]/Hirose Toshiyuki/Takahashi Masako/[長尾妙子]/[丹黒章]/Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancer-preliminary results./[The Journal of Medical Investigation : JMI]

著作: Honda Junko/Sasa Mitsunori/Moriya Takuya/[坂東良美]/Hirose Toshiyuki/Takahashi Masako/[長尾妙子]/[丹黒章]/Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancer-preliminary results./[The Journal of Medical Investigation : JMI]

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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

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共著種別

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学究種別

推奨

組織

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著者

必須

(英) Honda Junko

役割任意

貢献度任意

学籍番号推奨
(英) Sasa Mitsunori

役割任意

貢献度任意

学籍番号推奨
(英) Moriya Takuya

役割任意

貢献度任意

学籍番号推奨
坂東良美([徳島大学.病院.診療科.病理診断科])

役割任意

貢献度任意

学籍番号推奨
(英) Hirose Toshiyuki

役割任意

貢献度任意

学籍番号推奨
(英) Takahashi Masako

役割任意

貢献度任意

学籍番号推奨
長尾妙子

役割任意

貢献度任意

学籍番号推奨
丹黒章

役割任意

貢献度任意

学籍番号推奨

題名

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(英) Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancer-preliminary results.

副題

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要約

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(英) Capecitabine monotherapy was administered for 25 patients with advanced or recurrent breast cancer, and the clinical therapeutic efficacy and its relationship to expression of 5-fluorouracil-related enzymes (i. e., thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)) were investigated. The expressions of TP, TS and DPD were determined by immunohistochemical staining techniques and rated using a scoring system of 1~4. The expression score for TP/DPD showed a statistically significant correlation with the clinical response, whereas the expression score for TP/TS also showed a correlation but it was not statistically significant. The number of patients was small, but the results revealed the potential of application of the TP/DPD expression score as a factor for predicting the efficacy of the drug in individual patients.

キーワード

推奨

(英) Adult
(英) Aged
(英) Antimetabolites, Antineoplastic
(英) Breast Neoplasms
(英) Deoxycytidine
(英) Dihydrouracil Dehydrogenase (NADP)
(英) Female
(英) Fluorouracil
(英) Forecasting
(英) Humans
(英) Immunohistochemistry
(英) Middle Aged
(英) Retrospective Studies
(英) Therapeutic Equivalency
(英) Thymidine Phosphorylase
(英) Treatment Outcome

発行所

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誌名

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The Journal of Medical Investigation : JMI([徳島大学.医学部])

(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN	任意	1343-1420 ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMI Title(ISO): J Med Invest Supplier: 徳島大学 Publisher: University of Tokushima (NLM Catalog) (Webcat Plus) (医中誌Web) (J-STAGE) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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1-2

頁

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54 60

都市

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年月日

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2008年 2月初日

URL

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DOI

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10.2152/jmi.55.54 (→Scopusで検索)

PMID

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18319546 (→Scopusで検索)

CRID

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WOS

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Scopus

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機関リポジトリ

110839

評価値

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被引用数

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指導教員

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備考

任意

(英) Article.Affiliation: Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School, Tokushima, Japan.
(英) Article.PublicationTypeList.PublicationType: Journal Article

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University