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著作: Ohmori Keitaro/Luo Yuchun/Jia Yi/[西田 純]/Wang Zhengqi/Bunting D. Kevin/Wang Demin/Huang Hua/IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen./[The Journal of Immunology]

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EID
192555
EOID
653996
Map
0
LastModified
2012年8月28日(火) 20:24:07
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
西田 純
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種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Ohmori Keitaro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Luo Yuchun
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Jia Yi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 西田 純
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Wang Zhengqi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Bunting D. Kevin
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Wang Demin
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Huang Hua
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen.

副題 任意
要約 任意

(英) Recent work has established important roles for basophils in regulating immune responses. To exert their biological functions, basophils need to be expanded to critical numbers. However, the mechanisms underlying basophil expansion remain unclear. In this study, we established that IL-3 played an important role in the rapid and specific expansion of basophils. We found that the IL-3 complex (IL-3 plus anti-IL-3 Ab) greatly facilitated the differentiation of GMPs into basophil lineage-restricted progenitors (BaPs) but not into eosinophil lineage-restricted progenitors or mast cells in the bone marrow. We also found that the IL-3 complex treatment resulted in approximately 4-fold increase in the number of basophil/mast cell progenitors (BMCPs) in the spleen. IL-3-driven basophil expansion depended on STAT5 signaling. We showed that GMPs but not common myeloid progenitors expressed low levels of IL-3 receptor. IL-3 receptor expression was dramatically up-regulated in BaPs but not eosinophil lineage-restricted progenitors. Approximately 38% of BMCPs expressed the IL-3R alpha-chain. The up-regulated IL-3 receptor expression was not affected by IL-3 or STAT5. Our findings demonstrate that IL-3 induced specific expansion of basophils by directing GMPs to differentiate into BaPs in the bone marrow and by increasing the number of BMCPs in the spleen.

キーワード 推奨
  1. (英) Animals
  2. (英) Basophils
  3. (英) Cell Differentiation
  4. (英) Cell Lineage
  5. (英) Gene Expression Regulation
  6. (英) Granulocyte Precursor Cells
  7. (英) Granulocyte-Macrophage Progenitor Cells
  8. (英) Interleukin-3
  9. (英) Leukocyte Count
  10. (英) Mast Cells
  11. (英) Mice
  12. (英) Mice, Inbred C57BL
  13. (英) Mice, Knockout
  14. (英) Mice, Transgenic
  15. (英) Myeloid Progenitor Cells
  16. (英) Receptors, Interleukin-3
  17. (英) Spleen
  18. (英) Up-Regulation
発行所 推奨
誌名 必須 The Journal of Immunology([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
ISSN 任意 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 182
必須 5
必須 2835 2841
都市 任意
年月日 必須 2009年 3月 1日
URL 任意
DOI 任意 10.4049/jimmunol.0802870    (→Scopusで検索)
PMID 任意 19234178    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, CO 80206, USA.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't