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著作: [澤田 和彦]/[細井 英司]/[坂東 美和]/[坂田 ひろみ]/Lee N.S./Jeong Y.G/[福井 義浩]/Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya/[Neuroscience]

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EID
191738
EOID
887638
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0
LastModified
2018年2月9日(金) 13:26:45
Operator
三木 ちひろ
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Owner
細井 英司
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 澤田 和彦
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 細井 英司([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.細胞・免疫解析学]/[徳島大学.医学部.保健学科.検査技術科学専攻.機能系検査学講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 坂東 美和
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 坂田 ひろみ
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Lee N.S.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Jeong Y.G
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 福井 義浩
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya

副題 任意
要約 任意

(英) This study aimed to clarify changes in the spatial expressions of types 1, 2 and 3 ryanodine receptors (RyR1, RyR2 and RyR3) in the cerebellum of a Ca(2+) channel alpha(1A) subunit mutant, rolling mouse Nagoya. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) revealed that the mRNA signal levels of RyR1 and RyR3 were altered in the rolling cerebellum, which exhibited lower densities of RyR1 bands and higher densities of RyR3 bands than in the control cerebellum. Quite consistent with the RT-PCR results, the staining intensity of RyR1 and RyR3 was altered in the rolling cerebellum. RyR1 immunostaining appeared in somata and the proximal dendrites of Purkinje cells, and the staining intensity of both subcellular regions was equally lower in all cerebellar lobules of rolling mice than in those of controls. Although RyR3 immunostaining appeared in the dendrites of granule cells, more intense RyR3 staining in rolling mice than in controls was uniformly observed throughout all cerebellar lobules. The present study further examined co-localizations of ryanodine receptor subtypes and voltage-gated Ca(2+) channel alpha(1) subunits in the rolling cerebellum. Somatodendritic RyR1 immunostaining in Purkinje cells overlapped with either a mutated Ca(2+) channel alpha(1A) subunit (P/Q-type), or a Ca(2+) channel alpha(1C) subunit (L-type; dihydropyridine receptor) immunostaining. Immunostaining of these alpha(1) subunits also emerged in granule cells. Those results suggest non-region-related alterations in RyR1 and RyR3 expressions in the rolling mouse cerebellum. Such expressional changes in ryanodine receptor subtypes may be involved in Ca(2+) channel alpha(1A) subunit gene mutation, and may alter regulation of intracellular Ca(2+) concentrations in cerebellar cortical neurons.

キーワード 推奨
  1. (英) Animals
  2. (英) Calcium Channels, L-Type
  3. (英) Calcium Channels, Q-Type
  4. (英) Calcium Signaling
  5. (英) Cerebellar Ataxia
  6. (英) Cerebellar Cortex
  7. (英) Dendrites
  8. (英) Genetic Predisposition to Disease
  9. (英) Male
  10. (英) Mice
  11. (英) Mice, Neurologic Mutants
  12. (英) Neurons
  13. (英) Protein Isoforms
  14. (英) Protein Subunits
  15. (英) Purkinje Cells
  16. (英) RNA, Messenger
  17. (英) Reverse Transcriptase Polymerase Chain Reaction
  18. (英) Ryanodine Receptor Calcium Release Channel
  19. (英) Synaptic Transmission
発行所 推奨
誌名 必須 Neuroscience([International Brain Research Organization])
(pISSN: 0306-4522, eISSN: 1873-7544)
ISSN 任意 0306-4522
ISSN: 0306-4522 (pISSN: 0306-4522, eISSN: 1873-7544)
Title: Neuroscience
Title(ISO): Neuroscience
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 152
必須 3
必須 609 617
都市 任意
年月日 必須 2008年 1月 17日
URL 任意
DOI 任意 10.1016/j.neuroscience.2007.12.048    (→Scopusで検索)
PMID 任意 18313230    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Anatomy and Developmental Neurobiology, University of Tokushima Graduate School Institute of Health Biosciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. k-sawada@tius-hs.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't