著作: Takeda Saki/[板東 紀子]/[山西 倫太郎]/Ingested beta-carotene enhances glutathione level and up-regulates the activity of cysteine cathepsin in murine splenocytes./[Bioscience, Biotechnology, and Biochemistry]
ヘルプを読む
「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)
- 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.
|
|||||
種別 | 必須 | 学術論文(審査論文) | |||
---|---|---|---|---|---|
言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | Peer Review | |||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Ingested beta-carotene enhances glutathione level and up-regulates the activity of cysteine cathepsin in murine splenocytes. |
|||
副題 | 任意 | ||||
要約 | 任意 |
(英) To elucidate health benefits of beta-carotene, especially on immunity, we measured redox-related indices in spleen cells from BALB/c mice supplemented with various amounts of beta-carotene. In mice supplemented with beta-carotene in their diet, glutathione, an intracellular anti-oxidation agent, increased in their splenocytes. This change was highly correlated with the accumulation of beta-carotene, but not with that of retinol. The increase in glutathione was accompanied by an increase in mRNA for gamma-glutamylcysteine synthetase, a rate-limiting enzyme for glutathione synthesis. The higher the glutathione content was in the spleen cells, the higher the activity of cysteine cathepsin became in crude antigen-presenting cells contained in the spleen. These data suggest that accumulated beta-carotene in splenocytes, without being metabolized, caused an increase in the intracellular glutathione level, thereby anti-oxidatively supporting the activity of redox-sensitive lysosomal protease, which is involved in antigen-presentation. |
|||
キーワード | 推奨 |
|
|||
発行所 | 推奨 | ||||
誌名 | 必須 |
Bioscience, Biotechnology, and Biochemistry([社団法人 日本農芸化学会])
(pISSN: 0916-8451, eISSN: 1347-6947)
|
|||
巻 | 必須 | 72 | |||
号 | 必須 | 6 | |||
頁 | 必須 | 1595 1600 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2008年 6月 7日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1271/bbb.80102 (→Scopusで検索) | |||
PMID | 任意 | 18540097 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | 000257305300024 | |||
Scopus | 任意 | 2-s2.0-45849143974 | |||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
|