徳島大学 教育・研究者情報データベース(EDB)

1. (英) Kheirvari Sorayya

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2. 上江洲 香代子

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3. 山本 茂

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4. 中屋 豊

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(英) High-dose dietary supplementation of vitamin A induces brain-derived neurotrophic factor and nerve growth factor production in mice with simultaneous deficiency of vitamin A and zinc.

(英) Marginal vitamin A and zinc (Zn) deficiency often co-exist in many populations. Vitamin A plays a trophic role in brain and is important for its development. We investigated effects of dietary supplementation of vitamin A on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) production in mice depleted for vitamin A and Zn. After 3 months' feeding with a low vitamin A and Zn (LVA-LZ) diet, mice were divided into two groups and replenished with either normal or high vitamin A with low Zn diet for an additional 2 months. Levels of BDNF and NGF were measured from extracts of hippocampus, cortex and cerebellum at the end of the third and fifth months. The LVA-LZ group tended to show decreased amounts of the BDNF and NGF, while animals supplemented with high vitamin A along with Zn deficiency had high BDNF and NGF concentrations. From these results, we conclude that vitamin A may increase BDNF and NGF levels.

1. (英) Animals
2. (英) Brain-Derived Neurotrophic Factor
3. 小脳(cerebellum)
4. (英) Cerebral Cortex
5. (英) Diet
6. (英) Dietary Supplements
7. (英) Hippocampus
8. (英) Male
9. (英) Mice
10. (英) Nerve Growth Factor
11. (英) Specific Pathogen-Free Organisms
12. ビタミンA(vitamin A)
13. (英) Vitamin A Deficiency
14. 亜鉛(zinc)

1. (英) Article.Affiliation: Department of Nutrition and Metabolism, University of Tokushima Graduate School, Tokushima, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article