徳島大学 教育・研究者情報データベース(EDB)

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研究: [千田 淳司]/[生化学]

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EID
190419
EOID
489057
Map
0
LastModified
2009年12月3日(木) 20:38:08
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
千田 淳司
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研究者 必須 千田 淳司([徳島大学.先端酵素学研究所.基幹研究部門])
分野 必須
  1. 生化学(Biochemistry/[生物学]/[化学])
テーマ 必須
  1. (英) Development of ATP extraction and quantification kit from peripheral blood of patients

    (日) 患者の末梢血中の ATP レベルを測定する診断キットの開発

要約 任意

(英) Measurements of adenylate nucleotides (i.e., ATP, ADP) are used extensively to monitor energy stasis in broad range of cell types and tissues. For applications involving mammalian and other animal tissue, ATP are commonly extracted with chaotropic reagents particularly trichloroacetic acid (TCA) and perchloric acid (PCA). Physical methods for disintegration (boiling, sonic disintegration) have also used. As expected, these methods are suitable for measurements of cellular ATP, however these methods are inappropriate for histionic ATP because of the inefficiency of nucleotides extraction. Consequently, we have developed an integrated kit that includes software programs measuring tissue or total blood ATP. As the first step, we have evaluated the clinically usefulness of this system for determining blood ATP levels in patients with acute disease such as influenza-associated encephalopathy. It was found that various patients with severe disease have decreased blood ATP levels. It can be anticipated that in the abovementioned disease states, ATP measurement will become a valuable clinical parameter of great potential clinical importance.

キーワード 推奨
  1. アデノシン三リン酸(adenosine triphosphate)
  2. 多臓器不全(multiple organ failure)
共同研究 推奨
  1. (英) Clinical parameter for acute patients

    (日) 急性期患者の重症度診断

  2. (英) Assay of enzymes that produce or degrade ATP

    (日) 酵素反応による ATP 産生/分解の解析

優先度 任意 2
備考 任意