190411: Kobayashi Shu/Ikari Katsunori/Kaneko Hirotaka/Kochi Yuta/Yamamoto Kazuhiko/Shimane Kenichi/Nakamura Yusuke/Toyama Yoshiaki/Mochizuki Takeshi/Tsukahara So/Kawaguchi Yasushi/Terai Chihiro/Hara Masako/Tomatsu Taisuke/Yamanaka Hisashi/Horiuchi Takahiko/Tao Kayoko/[安友康二]/Hamada Daisuke/[安井夏生]/[井上寛]/[板倉光夫]/Okamoto Hiroshi/[鎌谷直之]/Momohara Shigeki/Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population./[Arthritis and Rheumatism]

著作: Kobayashi Shu/Ikari Katsunori/Kaneko Hirotaka/Kochi Yuta/Yamamoto Kazuhiko/Shimane Kenichi/Nakamura Yusuke/Toyama Yoshiaki/Mochizuki Takeshi/Tsukahara So/Kawaguchi Yasushi/Terai Chihiro/Hara Masako/Tomatsu Taisuke/Yamanaka Hisashi/Horiuchi Takahiko/Tao Kayoko/[安友康二]/Hamada Daisuke/[安井夏生]/[井上寛]/[板倉光夫]/Okamoto Hiroshi/[鎌谷直之]/Momohara Shigeki/Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population./[Arthritis and Rheumatism]

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EID: 190411
EOID: 876044
Map: 0
LastModified: 2017年11月27日(月) 18:36:00
Operator: 大家隆弘
Avail: TRUE
Censor: 0
Owner: 安井夏生
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種別

必須

学術論文(審査論文)

言語

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英語

招待

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審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

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(英) Kobayashi Shu

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学籍番号推奨
(英) Ikari Katsunori

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(英) Kaneko Hirotaka

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(英) Kochi Yuta

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学籍番号推奨
(英) Yamamoto Kazuhiko

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(英) Shimane Kenichi

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(英) Nakamura Yusuke

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(英) Toyama Yoshiaki

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(英) Mochizuki Takeshi

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(英) Tsukahara So

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(英) Kawaguchi Yasushi

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(英) Terai Chihiro

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(英) Hara Masako

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(英) Tomatsu Taisuke

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(英) Yamanaka Hisashi

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(英) Horiuchi Takahiko

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(英) Tao Kayoko

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安友康二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])

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(英) Hamada Daisuke

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安井夏生

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井上寛

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板倉光夫

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(英) Okamoto Hiroshi

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鎌谷直之([徳島大学.ゲノム機能研究センター])

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(英) Momohara Shigeki

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題名

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(英) Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population.

副題

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要約

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(英) OBJECTIVE: STAT4 encodes a transcriptional factor that transmits signals induced by several key cytokines, and it might be a key molecule in the development of autoimmune diseases. Recently, a STAT4 haplotype was reported to be associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in Caucasian populations. This was replicated in a Korean RA population. Interestingly, the degree of risk of RA susceptibility with the STAT4 haplotype was similar in the Caucasian and Korean populations. The present study was undertaken to investigate the effect of STAT4 on susceptibility to RA and SLE in the Japanese. METHODS: We performed an association study using 3 independent Japanese RA case-control populations (total 3,567 cases and 2,199 controls) and 3 independent Japanese SLE populations (total 591 cases). All samples were genotyped using the TaqMan fluorogenic 5' nuclease assay for single-nucleotide polymorphism (SNP) rs7574865, which tags the susceptibility haplotype. The association of the SNP with disease susceptibility in each case-control study was calculated using Fisher's exact test, and the results were combined, using the Mantel-Haenszel method, to obtain combined odds ratios (ORs). RESULTS: We observed a significant association of the STAT4 polymorphism with susceptibility to both RA and SLE. The combined ORs for RA and SLE, respectively, were 1.27 (P = 8.4 x 10(-9)) and 1.61 (P = 2.1 x 10(-11)) for allele frequency distribution; these ORs were quite similar to those previously observed in the Caucasian population. CONCLUSION: We conclude that STAT4 is associated with RA and SLE in the Japanese. Our results indicate that STAT4 is a common genetic risk factor for autoimmune diseases, with similar strength across major racial groups.

キーワード

推奨

(英) Aged
(英) Arthritis, Rheumatoid
(英) Case-Control Studies
(英) Female
(英) Genetic Predisposition to Disease
(英) Haplotypes
(英) Humans
(英) Japan
(英) Lupus Erythematosus, Systemic
(英) Male
(英) Middle Aged
(英) Polymorphism, Single Nucleotide
(英) Risk Factors
(英) STAT4 Transcription Factor

発行所

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誌名

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Arthritis and Rheumatism(American Rheumatism Association/Arthritis Foundation/American Rheumatism Association/American College of Rheumatology)

(pISSN: 0004-3591, eISSN: 1529-0131)

ISSN	任意	0004-3591 ISSN: 0004-3591 (pISSN: 0004-3591, eISSN: 1529-0131) Title: Arthritis and rheumatism Title(ISO): Arthritis Rheum Publisher: John Wiley & Sons Inc. (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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1940 1946

都市

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年月日

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2008年 7月初日

URL

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DOI

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10.1002/art.23494 (→Scopusで検索)

PMID

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18576330 (→Scopusで検索)

CRID

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WOS

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000257469800008

Scopus

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被引用数

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指導教員

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備考

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(英) Article.Affiliation: Tokyo Women's Medical University, Tokyo, Japan.
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University