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著作: Yamamura Rie/[西村 範行]/[中逵 弘能]/[荒瀬 誠治]/[佐々木 卓也]/The Interaction of JRAB/MICAL-L2 with Rab8 and Rab13 Coordinates the Assembly of Tight Junctions and Adherens Junctions./[Molecular Biology of the Cell]

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EID
189901
EOID
664101
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0
LastModified
2012年10月9日(火) 18:29:38
Operator
大家 隆弘
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Owner
佐々木 卓也
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Yamamura Rie
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 西村 範行
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 中逵 弘能
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 荒瀬 誠治
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 佐々木 卓也([徳島大学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) The Interaction of JRAB/MICAL-L2 with Rab8 and Rab13 Coordinates the Assembly of Tight Junctions and Adherens Junctions.

副題 任意
要約 任意

(英) The assembly of tight junctions (TJs) and adherens junctions (AJs) is regulated by the transport of integral TJ and AJ proteins to and/or from the plasma membrane (PM) and it is tightly coordinated in epithelial cells. We previously reported that Rab13 and a junctional Rab13-binding protein (JRAB)/molecule interacting with CasL-like 2 (MICAL-L2) mediated the endocytic recycling of an integral TJ protein occludin and the formation of functional TJs. Here, we investigated the role of Rab13 and JRAB/MICAL-L2 in the transport of other integral TJ and AJ proteins claudin-1 and E-cadherin to the PM by using a Ca(2+)-switch model. Although knockdown of Rab13 specifically suppressed claudin-1 and occludin but not E-cadherin transport, knockdown of JRAB/MICAL-L2 and expression of its Rab13-binding domain (JRAB/MICAL-L2-C) inhibited claudin-1, occludin, and E-cadherin transport. We then identified Rab8 as another JRAB/MICAL-L2-C-binding protein. Knockdown of Rab8 inhibited the Rab13-independent transport of E-cadherin to the PM. Rab8 and Rab13 competed with each other for the binding to JRAB/MICAL-L2 and functionally associated with JRAB/MICAL-L2 at the perinuclear recycling/storage compartments and PM, respectively. These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of AJs and TJs.

キーワード 推奨
  1. (英) Adherens Junctions
  2. (英) Animals
  3. (英) Binding, Competitive
  4. (英) Cadherins
  5. (英) Cell Line
  6. (英) Cytoskeletal Proteins
  7. (英) Endocytosis
  8. (英) Humans
  9. (英) Intracellular Space
  10. (英) Membrane Proteins
  11. (英) Models, Biological
  12. (英) Protein Binding
  13. (英) Protein Structure, Tertiary
  14. (英) Protein Transport
  15. (英) Tight Junctions
  16. (英) rab GTP-Binding Proteins
発行所 推奨
誌名 必須 Molecular Biology of the Cell(The American Society for Cell Biology)
(pISSN: 1059-1524, eISSN: 1939-4586)
ISSN 任意 1939-4586
ISSN: 1059-1524 (pISSN: 1059-1524, eISSN: 1939-4586)
Title: Molecular biology of the cell
Title(ISO): Mol Biol Cell
Publisher: American Society for Cell Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 19
必須 3
必須 971 983
都市 任意
年月日 必須 2008年 3月 初日
URL 任意
DOI 任意 10.1091/mbc.E07-06-0551    (→Scopusで検索)
PMID 任意 18094055    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) OtherID: PMC2262956