著作: Kanda I./[西村 範行]/Nakatsuji H./Yamamura R./[中西 秀樹]/[佐々木 卓也]/Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering./[Oncogene]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) Epithelial cell scattering recapitulates the first steps of carcinoma invasion/metastasis. While the balance between cell-cell adhesive activity and cell motility ultimately determines this process, its molecular mechanisms remain unclear. Adherence junctions and tight junctions (TJs) are primarily responsible for cell-cell adhesive activity and subjected to dynamic remodeling. We previously showed that Rab13 and its effector protein JRAB/MICAL-L2 mediate the endocytic recycling of the integral TJ protein occludin and the assembly of functional TJs. In this study, we examined the role of Rab13 and JRAB/MICAL-L2 in the scattering of Madin-Darby canine kidney (MDCK) cells in response to 12-O-tetradecanoylphorbol-13-acetate (TPA). Knockdown of Rab13 in canine MDCK cells suppressed the TPA-induced scattering, and this phenotype was restored by re-expression of human Rab13. During TPA-induced MDCK cell scattering, Rab13 was transiently activated and returned to its basal level, and both Rab13 and JRAB/MICAL-L2 were colocalized with F-actin at cell-cell contact sites and then accumulated at emerging lamellipodial structures. TPA-induced MDCK cell scattering was also inhibited by knockdown of canine JRAB/MICAL-L2 and rescued by re-expression of mouse JRAB/MICAL-L2. These results indicate that Rab13 and JRAB/MICAL-L2 are involved in epithelial cell scattering. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
Oncogene([Nature Publishing Group])
(pISSN: 0950-9232, eISSN: 1476-5594)
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巻 | 必須 | 27 | |||
号 | 必須 | 12 | |||
頁 | 必須 | 1687 1695 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2008年 3月 13日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1038/sj.onc.1210812 (→Scopusで検索) | |||
PMID | 任意 | 17891173 (→Scopusで検索) | |||
NAID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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