著作: [西村 範行]/[佐々木 卓也]/Rab family small G proteins in regulation of epithelial apical junctions./[Frontiers in Bioscience]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 |
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著者 | 必須 | ||||
題名 | 必須 |
(英) Rab family small G proteins in regulation of epithelial apical junctions. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) Tight junctions (TJs) and adherens junctions (AJs) comprise epithelial apical junctions that adhere neighboring epithelial cells and determine tissue organization. They are highly dynamic structures that undergo continuous remodeling during physiological morphogenesis and under pathological conditions. The assembly and disassembly of epithelial apical junctions is regulated by the interplay between a variety of cellular processes, such as the remodeling of actin cytoskeletons and the endocytic recycling of apical junctional proteins, and coordinated by many signaling pathways. Accumulating evidences demonstrate that Rab family small G proteins are crucially involved in the regulation of epithelial apical junctions. Rab proteins localized both at endosomes and apical junctions can influence the assembly and disassembly of epithelial apical junctions. In this review, we summarize how Rab proteins influence epithelial apical junctions and describe the role of Rab8/13-a junctional Rab13-binding protein (JRAB)/molecule interacting with CasL-like 2 (MICAL-L2) complexes in the regulation of epithelial apical junctions. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
Frontiers in Bioscience(Frontiers in Bioscience Publications)
(pISSN: 1093-9946, eISSN: 1093-4715)
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巻 | 必須 | 14 | |||
号 | 必須 | --- | |||
頁 | 必須 | 2115 2129 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2009年 1月 1日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.2741/3366 (→Scopusで検索) | |||
PMID | 任意 | 19273188 (→Scopusで検索) | |||
NAID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | ||||
評価値 | 任意 | ||||
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指導教員 | 推奨 | ||||
備考 | 任意 |
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