徳島大学 教育・研究者情報データベース(EDB)

1. (英) Ahn Mok-Ryeon

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2. (英) Kunimasa Kazuhiro

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3. (英) Kumazawa Shigenori

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4. (英) Nakayama Tsutomu

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5. (英) Kaji Kazuhiko

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6. 宇都 義浩([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])

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7. 堀 均

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8. 永澤 秀子(岐阜薬科大学/->個人[紺世 秀子])

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9. (英) Ohta Toshiro

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(英) Correlation between antiangiogenic activity and antioxidant activity of various components from propolis

(英) Propolis possesses various physiological activities. In this study, we examined the antiangiogenic and antioxidant activities of various components from propolis: acacetin, apigenin, artepillin C, caffeic acid phenethyl ester, chrysin, p-coumaric acid, galangin, kaempferol, pinocembrin, and quercetin. The effects of these components were tested on in vitro models of angiogenesis, tube formation and growth of human umbilical vein endothelial cells (HUVECs). Furthermore, these components were evaluated for their antioxidant activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging and ferric reducing/antioxidant power (FRAP) assays. Two propolis components, caffeic acid phenethyl ester, and quercetin, possessed strong inhibitory effects on tube formation and on endothelial cell proliferation and, coincidentally, showed strong antioxidant activity. Artepillin C, galangin, and kaempferol also possessed strong antiangiogenic and antioxidant activities to a slightly less degree. In contrast, acacetin, apigenin, and pinocembrin possessed a considerable degree of antiangiogenic activities, although they showed very low antioxidant activities. From these results, we propose that components from propolis such as artepillin C, caffeic acid phenethyl ester, galangin, kaempferol, and quercetin might represent a new class of dietary-derived antioxidative compounds with antiangiogenic activities. These propolis components may have the potential to be developed into pharmaceutical drugs for the treatment of angiogenesis-dependent human diseases such as tumors.

1. (英) Angiogenesis

   データベース中に適合する可能性のある以下の情報を発見しました

   [キーワード] 血管新生 (angiogenesis)

2. (英) Antioxidant

   データベース中に適合する可能性のある以下の情報を発見しました

   [キーワード] 抗酸化物質 (antioxidant)

3. (英) Human umbilical vein endothelial cells
4. (英) Propolis
5. (英) Tube formation

1. (英) Article.Affiliation: Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka, Shizuoka, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't