徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.病態予防医学講座.生理機能学(2004年4月1日〜2015年3月31日)
2. 徳島大学.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.情報統合医学講座.統合生理学(2004年4月1日〜2015年3月31日)
3. 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.医療栄養科学講座.臨床食管理学(2004年4月1日〜2015年3月31日)

1. 北岡 和義([徳島大学.教養教育院])

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2. (英) Uchida Kaoru / (日) 内田 薫

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3. (英) Okamoto Naoko / (日) 岡本 直子

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4. 近久 幸子

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5. (英) Miyazaki Toshitsugu / (日) 宮崎 寿次

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6. 武田 英二

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7. 勢井 宏義([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.生理学])

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(英) Fermented ginseng improves the first-night effect in humans

(英) The goal of this study was to clarify whether ginseng fermented by lactic acid bacteria (fermented ginseng, FG), can improve the first-night effect (FNE) in humans. Behavioral tests and quantification of mRNA expression related to GABAergic neurotransmission in brain (glutamic acid decarboxylase 1, gamma-aminobutyrate aminotransferase [Abat], gamma-aminobutyric acid transporter 1 [GAT1], gamma-aminobutyric acid transporter 4, gamma-aminobutyric acid A receptor subunit alpha 1 and gamma-aminobutyric acid A receptor subunit alpha 2) were carried out in FG-treated mice. We also performed double-blind sleep recordings of human subjects given FG or placebo. A university-based sleep laboratory. Sixteen healthy male volunteers (aged 20.69 +/- 0.44 years) were observed in the human study. At the end of administration, 2 consecutive all-night polysomnography recordings were performed. Subjects also completed psychological questionnaires, and urine and saliva samples were taken to analyze stress-sensitive markers. The light-dark transition test demonstrated that FG had some anxiolytic effect in mice, but other anxiety measures were unaffected. The hippocampal mRNA expression showed a decrease of Abat and GAT1 suggesting an increase of GABA. Other regions (amygdala and cerebellum) showed no differences. Furthermore, there was some evidence (using simple pairwise comparisons but not supported in the full ANOVA model) that administration of FG tended to diminish decreases in total sleep time and sleep efficiency (seen as first night effects in the placebo group) without affecting sleep architecture. Our results suggest the administration of FG could improve the FNE in humans. The improvement may be related to an anxiolytic effect of FG which acts via GABAergic modification.

1. 睡眠(sleep)

1. (英) Article.Affiliation: Department of Integrative Physiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial

4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

5. (英) OtherID: PMC2647796