徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: Nakamuta Shinichi/Endo Hiroshi/Higashi Youichiro/Kousaka Aoi/Kousaka Aoi/[矢野 仁康]/[木戸 博]/HIV-1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells/[Journal of NeuroVirology]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
187439
EOID
692624
Map
0
LastModified
2013年6月27日(木) 10:50:03
Operator
松井 栄里
Avail
TRUE
Censor
0
Owner
木戸 博
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Nakamuta Shinichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Endo Hiroshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Higashi Youichiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kousaka Aoi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kousaka Aoi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 矢野 仁康
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 木戸 博([徳島大学.先端酵素学研究所.重点研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) HIV-1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells

副題 任意
要約 任意

(英) The infiltration of human immunodeficiency virus (HIV)-1, such as by HIV-infected leukocytes, across an injured blood-brain barrier (BBB) is a characteristic pathologic manifestation of HIV-1-associated dementia. HIV-1 gp120 has been implicated as a cause of breakdown of tight junctions between endothelial cells of the BBB, though the disrupting molecular mechanisms are unexplained. This study offers a new explanation for the increased BBB microvascular permeability, due to the degradation of tight junction proteins by the proteasome induced by gp120, and the negative regulation of this process by the scaffold protein, 14-3-3tau. gp120 reduced the amount of zonula occludens (ZO)-1 and ZO-2 in human brain microvascular endothelial cells (HBMECs). The treatment of HBMECs with the proteasome inhibitor, lactacystin, blocked the degradation of ZO-1 and ZO-2, suggesting that these proteins were targeted by gp120 for degradation by the proteasome. gp120 also specifically increased the expression of 14-3-3tau in HBMECs, and its down-regulation by RNAi facilitated the breakdown of tight junction proteins induced by gp120. Our results demonstrate the novel molecular mechanisms of the BBB breakdown by gp120.

キーワード 推奨
  1. (英) 14-3-3 Proteins
  2. (英) AIDS Dementia Complex
  3. 血液脳関門(blood-brain barrier)
  4. (brain)
  5. (英) Capillary Permeability
  6. (英) Cells, Cultured
  7. (英) Endothelial Cells
  8. (英) Endothelium, Vascular
  9. (英) Gene Expression Regulation
  10. (英) HIV Envelope Protein gp120
  11. (英) HIV-1
  12. (英) Humans
  13. (英) Membrane Proteins
  14. (英) Phosphoproteins
  15. (英) Proteasome Endopeptidase Complex
  16. (英) Tight Junctions
  17. (英) Transcriptional Activation
発行所 推奨
誌名 必須 Journal of NeuroVirology(International Society for NeuroVirology)
(pISSN: 1355-0284, eISSN: 1538-2443)
ISSN 任意 1538-2443
ISSN: 1355-0284 (pISSN: 1355-0284, eISSN: 1538-2443)
Title: Journal of neurovirology
Title(ISO): J Neurovirol
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 14
必須 3
必須 186 195
都市 任意
年月日 必須 2008年 5月 初日
URL 任意
DOI 任意 10.1080/13550280801993630    (→Scopusで検索)
PMID 任意 18569453    (→Scopusで検索)
NAID 任意
WOS 任意 000256978400002
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: The Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't