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著作: [銭 志栄]/Asa L Sylvia/[塩見 春彦]/[塩見 美喜子]/[吉本 勝彦]/Yamada Shozo/Wang Lu Elaine/Rahman Mustafizur Md/[井上 寛]/[板倉 光夫]/[工藤 英治]/[佐野 壽昭]/Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas./[Modern Pathology]

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EID
187229
EOID
657043
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0
LastModified
2012年9月2日(日) 21:35:37
Operator
大家 隆弘
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Owner
吉本 勝彦
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 銭 志栄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Asa L Sylvia
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 塩見 春彦
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 塩見 美喜子
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 吉本 勝彦
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Yamada Shozo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Wang Lu Elaine
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Rahman Mustafizur Md
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 井上 寛
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. 板倉 光夫
    役割 任意
    貢献度 任意
    学籍番号 推奨
  11. 工藤 英治
    役割 任意
    貢献度 任意
    学籍番号 推奨
  12. 佐野 壽昭
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas.

副題 任意
要約 任意

(英) High-mobility group A2 is highly expressed during embryogenesis and in various benign and malignant tumors. Recent studies report that high-mobility group A2 is negatively regulated by the let-7 microRNAs (miRNAs) family in vitro. The development of pituitary adenomas in high-mobility group A2 transgenic mice showed that high-mobility group A2 may be involved in pituitary tumorigenesis. However, no studies have investigated the clinical significance of high-mobility group A2 and its relationship to the let-7 miRNA family in human pituitary adenomas. Using immunohistochemistry, we analyzed high-mobility group A2 expression with respect to various clinicopathologic factors in 98 pituitary adenomas. Overexpression of high-mobility group A2 was observed in 39% (38/98) of pituitary adenomas compared with normal adenohypophysial tissue and was frequently found in adenomas including prolactin (PRL), adrenocorticotrophic hormone, or follicle-stimulating hormone/luteinizing hormone and in null cell adenomas, but relatively rare in growth hormone (GH) and mixed GH/PRL adenomas. High-mobility group A2 expression was significantly associated with tumor invasion (P<0.05) and was significantly higher in grade IV than in grades I, II, and III adenomas (P<0.05). High levels of high-mobility group A2 expression were more frequently observed in macroadenomas than in microadenomas (P<0.05). High levels of high-mobility group A2 expression also significantly correlated with the proliferation marker Ki-67 (P<0.0001). Real-time quantitative RT-PCR analysis was carried out to evaluate the expression of let-7 in 55 pituitary adenomas. Subsequently, decreased expression of let-7 was confirmed in 23 of 55 (42%) adenomas and was correlated with high-grade tumors (P<0.05). An inverse correlation between let-7 and high-mobility group A2 expression was evident (R=-0.33, P<0.05). These findings support a causal link between let-7 and high-mobility group A2 whereby loss of let-7 expression induces high-mobility group A2 upregulation that represents an important mechanism in pituitary tumorigenesis and progression.

キーワード 推奨
  1. (英) Adenoma
  2. (英) Disease Progression
  3. (英) Female
  4. (英) Gene Expression
  5. (英) HMGA2 Protein
  6. (英) Humans
  7. (英) Immunohistochemistry
  8. (英) Male
  9. (英) MicroRNAs
  10. (英) Pituitary Neoplasms
  11. (英) Reverse Transcriptase Polymerase Chain Reaction
  12. (英) Tumor Markers, Biological
  13. (英) Up-Regulation
発行所 推奨
誌名 必須 Modern Pathology(United States and Canadian Academy of Pathology)
(pISSN: 0893-3952, eISSN: 1530-0285)
ISSN 任意 1530-0285
ISSN: 0893-3952 (pISSN: 0893-3952, eISSN: 1530-0285)
Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Title(ISO): Mod Pathol
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 22
必須 3
必須 431 441
都市 任意
年月日 必須 2009年 1月 9日
URL 任意
DOI 任意 10.1038/modpathol.2008.202    (→Scopusで検索)
PMID 任意 19136928    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School of Medicine, Tokushima, Japan. zrqian@basic.med.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't