徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.疾患プロテオゲノム研究センター(2008年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.プロテオゲノム研究領域])

1. 棚橋 俊仁

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2. (英) Shinohara Keiko

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3. (英) Keshavarz Parvaneh

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4. (英) Yamaguchi Yuka

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5. 宮脇 克行([徳島大学.バイオイノベーション研究所]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])

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6. (英) Kunika Kiyoshi

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7. 森谷 眞紀(香川小児病院)

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8. (英) Nakamura Naoto

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9. 吉川 敏一([京都府立医科大学])

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10. 塩田 洋

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11. 井上 寛

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12. 板倉 光夫

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(英) The association of genetic variants in Krüppel-like factor 11 and Type 2 diabetes in the Japanese population.

(英) Krüppel-like factor 11 (KLF11) is a transcriptional factor of the zinc finger domain family that regulates the expression of insulin. In North European populations, its common functional variant Q62R (rs35927125) is a strong genetic factor for Type 2 diabetes (P = 0.00033, odds ratio for G allele = 1.29, 95% CI 1.12-1.49). We examined the contribution of KLF11 variants to the susceptibility to Type 2 diabetes in a Japanese population. By re-sequencing Japanese individuals (n = 24, partly 96), we screened all four exons, exon/intron boundaries and flanking regions of KLF11. Verified single nucleotide polymorphisms (SNPs) were genotyped in 731 initial samples (369 control and 362 case subjects). Subsequently, we tested for association in 1087 samples (524 control and 563 case subjects), which were collected in different districts of Japan from the initial samples. We identified eight variants, including a novel A/C variant on intron 3, but no mis-sense mutations. In an association study, we failed to find any significant result of SNPs (minor allele frequency 8.2-46.2%) after correcting for multiple testing. Similarly, no haplotypes were associated with Type 2 diabetes. It is notable that the G allele in rs35927125 was completely absent in 1818 Japanese individuals. Genetic variants in KLF11 are unlikely to have a major effect of Type 2 diabetes in the Japanese population, although they were significantly associated in North European populations. These observations might help to determine the role of KLF11 variants in Type 2 diabetes in different populations.

1. (英) Adult
2. (英) Analysis of Variance
3. (英) Asian Continental Ancestry Group
4. (英) Cell Cycle Proteins
5. (英) Diabetes Mellitus, Type 2
6. (英) Female
7. (英) Gene Frequency
8. (英) Genetic Predisposition to Disease
9. (英) Genotype
10. (英) Humans
11. (英) Insulin
12. (英) Japan
13. (英) Linkage Disequilibrium
14. (英) Male
15. (英) Middle Aged
16. (英) Repressor Proteins

1. (英) Article.Affiliation: Division of Genetic Information, Institute for Genome Research, University of Tokushima, Tokushima, Japan. tana@genome.tokushima-u.ac.jp

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

4. (英) OtherID: PMC3228237