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著作: [新田 剛]/Murata Shigeo/[上野 智雄]/Tanaka Keiji/[高浜 洋介]/Thymic microenvironments for T-cell repertoire formation./[Advances in Immunology]

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EID
185197
EOID
701093
Map
0
LastModified
2013年8月12日(月) 13:51:17
Operator
松井 栄里
Avail
TRUE
Censor
0
Owner
高浜 洋介
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 新田 剛
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Murata Shigeo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 上野 智雄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Tanaka Keiji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 高浜 洋介
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Thymic microenvironments for T-cell repertoire formation.

副題 任意
要約 任意

(英) Functionally competent immune system includes a functionally competent T-cell repertoire that is reactive to foreign antigens but is tolerant to self-antigens. The repertoire of T cells is primarily formed in the thymus through positive and negative selection of developing thymocytes. Immature thymocytes that undergo V(D)J recombination of T-cell antigen receptor (TCR) genes and that express the virgin repertoire of TCRs are generated in thymic cortex. The recent discovery of thymoproteasomes, a molecular complex specifically expressed in cortical thymic epithelial cells (cTEC), has revealed a unique role of cTEC in cuing the further development of immature thymocytes in thymic cortex, possibly by displaying unique self-peptides that induce positive selection. Cortical thymocytes that receive TCR-mediated positive selection signals are destined to survive for further differentiation and are induced to express CCR7, a chemokine receptor. Being attracted to CCR7 ligands expressed by medullary thymic epithelial cells (mTEC), CCR7-expressing positively selected thymocytes relocate to thymic medulla. The medullary microenvironment displays another set of unique self-peptides for trimming positively selected T-cell repertoire to establish self-tolerance, via promiscuous expression of tissue-specific antigens by mTEC and efficient antigen presentation by dendritic cells. Recent results demonstrate that tumor necrosis factor (TNF) superfamily ligands, including receptor activating NF-kappaB ligand (RANKL), CD40L, and lymphotoxin, are produced by positively selected thymocytes and pivotally regulate mTEC development and thymic medulla formation.

キーワード 推奨
  1. (英) Animals
  2. (英) Autoimmunity
  3. (英) Cell Differentiation
  4. (英) Clonal Deletion
  5. (英) Dendritic Cells
  6. (英) Epithelial Cells
  7. (英) Humans
  8. (英) Receptors, Antigen, T-Cell
  9. (英) Receptors, CCR7
  10. (英) Self Tolerance
  11. (英) T-Lymphocyte Subsets
  12. (英) Thymus Gland
発行所 推奨
誌名 必須 Advances in Immunology([Elsevier])
(pISSN: 0065-2776, eISSN: 1557-8445)
ISSN 任意 0065-2776
ISSN: 0065-2776 (pISSN: 0065-2776, eISSN: 1557-8445)
Title: Advances in immunology
Title(ISO): Adv Immunol
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus (Scopus information is found. [need login])
必須 99
必須
必須 59 94
都市 任意
年月日 必須 2008年 0月 初日
URL 任意
DOI 任意 10.1016/S0065-2776(08)00603-2    (→Scopusで検索)
PMID 任意 19117532    (→Scopusで検索)
NAID 任意
WOS 任意 000262126600003
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Review

  5. (英) NumberOfReferences: 260