徳島大学 教育・研究者情報データベース(EDB)

1. 大学院ヘルスバイオサイエンス研究部(2004年4月1日〜2015年3月31日/->組織[徳島大学.大学院医歯薬学研究部])

1. (英) Miyake Kotaro

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. 島田 光生([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. 西岡 将規(->個人[發知 将規])

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Sugimoto Koji

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Batmunkh Erdenebulgan

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. 宇都 義浩([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. 永澤 秀子(岐阜薬科大学/->個人[紺世 秀子])

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 堀 均

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer.

(英) Tumor hypoxia has been considered to be a potential therapeutic target, because hypoxia is a common feature of solid tumors and is associated with their malignant phenotype. In the present study, we investigated the antitumor effect of hypoxic cell radiosensitizer, TX-1877 in inhibiting angiogenesis and liver metastasis on pancreatic cancer xenograft model. The antitumor effects of TX-1877 were tested against various human tumor cell lines using cell proliferation assay. Nude mice bearing s.c. or orthotopically implanted human SUIT-2 were treated with TX-1877 alone, irradiation alone or TX-1877 and irradiation. Tumor volume, survival, expression of angiogenic molecules and liver metastasis were evaluated in treatment versus control groups. In vitro, TX-1877 inhibited the proliferation and potentiated the radiosensitivity of various pancreatic cancer cell lines. In an orthotopic model, tumors from nude mice injected with pancreatic cancer cells and treated with TX-1877 and irradiation showed significant reductions in volume (p<0.05 versus control, TX-1877 alone or irradiation alone). Quantitative real-time reverse transcription-PCR and immunohistochemical analysis revealed that treatment with TX-1877 alone or with TX-1877 and irradiation inhibited expression of the angiogenic molecules, vascular endothelial growth factor; basic fibroblast growth factor, interleukin-8 and matrix metalloproteinase 9 more than control or did treatment with irradiation alone. These treatments also induced apoptosis in cancer cells. These data show that treatment of TX-1877 and irradiation decreased growth of human pancreatic cancer, suppressed angiogenesis and inhibited liver metastasis, leading to prolonged survival.

1. (英) Antineoplastic Agents
2. (英) Cell Hypoxia
3. (英) Cell Line, Tumor
4. (英) Humans
5. (英) Immunohistochemistry

   データベース中に適合する可能性のある以下の情報を発見しました

   [キーワード] 免疫組織化学 (immunohistochemistry)

6. (英) In Situ Nick-End Labeling
7. (英) Liver Neoplasms
8. (英) Neovascularization, Pathologic
9. (英) Nitroimidazoles
10. (英) Pancreatic Neoplasms
11. (英) Radiation-Sensitizing Agents
12. (英) Reverse Transcriptase Polymerase Chain Reaction
13. (英) Transplantation, Heterologous

1. (英) Article.Affiliation: Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima City, Tokushima 770-8503, Japan. kota166@clin.med.tokushima-u.ac.jp

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't