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著作: [水野 大]/Kubo Itsuka/Ide-Kurihara Mikiko/Ichinomiya Tomoko/[木戸 博]/Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen/[The Journal of Immunology]

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EID
179790
EOID
726067
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LastModified
2014年2月28日(金) 15:45:51
Operator
三木 ちひろ
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Owner
木戸 博
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.疾患酵素学研究センター(2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域])
著者 必須
  1. 水野 大
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kubo Itsuka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Ide-Kurihara Mikiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Ichinomiya Tomoko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 木戸 博([徳島大学.先端酵素学研究所.重点研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen

副題 任意
要約 任意

(英) The intranasal administration of influenza hemagglutinin (HA) vaccine with Surfacten, a modified pulmonary surfactant free of antigenic c-type lectins, as a mucosal adjuvant induced the highest protective mucosal immunity in the airway. The intranasal immunization of mice with HA vaccine (0.2 microg)-Surfacten (0.2 microg) selectively induced the neutralizing anti-HA IgA, but not IgG, and conferred nearly maximal protection in the airway, without inducing a systemic response. In contrast, intranasal inoculation of vaccine with 0.2 microg of the potent mucosal adjuvant cholera toxin B* (CT-B*), prepared by adding 0.2% native CT to the B subunit of CT, induced both anti-HA IgA and IgG in the airway and in the serum. The intranasal administration of HA vaccine alone induced a limited amount of mucosal IgA against influenza virus. Although the s.c. administration of HA vaccine prominently induced serum IgG and IgA, Surfacten and CT-B* did not enhance their induction, and the concentrations of Abs leaking into the airways were insufficient to prevent viral multiplication. The intranasal administration of HA-Surfacten stimulated the expression of MHC class II, CD40, and CD86 molecules in the CD11c-positive cells isolated from the nasal mucosa, but not the expression of cells from the lungs or spleens. Lymphocytes isolated from the airway mucosa after intranasal HA-Surfacten immunization prominently induced TGF-beta1 which, compared with inoculation without Surfacten, promoted an Ag-specific mucosal IgA response. Surfacten alone, however, did not induce TGF-beta1. Our observations suggest that Surfacten, by mimicking the natural surfactant, is an effective mucosal adjuvant in the process of airway immunization.

キーワード 推奨
  1. (英) Administration, Intranasal
  2. (英) Animals
  3. (英) Antibodies, Viral
  4. (英) Antigen-Presenting Cells
  5. (英) Antigens, Viral
  6. 細胞質分裂(cytokinesis)
  7. (英) Dose-Response Relationship, Immunologic
  8. (英) Female
  9. (英) Hemagglutinin Glycoproteins, Influenza Virus
  10. (英) Immunity, Mucosal
  11. (英) Immunoglobulin A, Secretory
  12. (英) Immunoglobulin G
  13. (英) Immunologic Factors
  14. (英) Influenza A virus
  15. (英) Influenza Vaccines
  16. (英) Mice
  17. (英) Mice, Inbred BALB C
  18. (英) Nasal Mucosa
  19. (英) Neutralization Tests
  20. (英) Pulmonary Surfactants
  21. (英) Transforming Growth Factor beta
  22. (英) Transforming Growth Factor beta1
発行所 推奨
誌名 必須 The Journal of Immunology([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
ISSN 任意 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 176
必須 2
必須 1122 1130
都市 任意
年月日 必須 2006年 1月 15日
URL 任意
DOI 任意
PMID 任意 16394001    (→Scopusで検索)
NAID 任意
WOS 任意 000234553800055
Scopus 任意 2-s2.0-30744461365
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: In Vitro

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't