徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座(2004年4月1日〜2015年3月31日)

1. (英) Nishimune Yoshitake

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2. 羽地 達次

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3. (英) Kitamura Yukihiko

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(英) The effects of steel mutation on testicular germ cell differentiation

(英) The effects of artificial cryptorchidism and its surgical reversal on spermatogenesis were examined in germ cell mutant, S1/+ and wild type, +/+, mice. In cryptorchid testes no difference was found between S1/+ and +/+ mice in the number of undifferentiated type A spermatogonia. The activity of type A spermatogonia in mutant mice appeared normal as judged by its mitotic cell number and DNA synthesis. The surgical reversal of cryptorchidism resulted in regenerative differentiation of mature germ cells in both types of mice, but the pattern of cellular differentiation in the mutant testes was completely different from that of the wild type testes. At two steps of cellular differentiation, intermediate or type B spermatogonia and spermatid, the numbers of cells were much smaller in the S1/+ testes than those in the +/+ testes. The steel gene was therefore suggested to exert its effects on the differentiation of type A spermatogonia to intermediate or type B spermatogonia, on meiotic division and/or the survival rate of these cells, but not on the undifferentiated type A spermatogonia or stem cells.

1. (英) Animals
2. (英) Cryptorchidism
3. DNA(DNA)
4. (英) Genes
5. (英) Genitalia, Male
6. (英) Male
7. (英) Meiosis
8. (英) Mice
9. (英) Mutation
10. (英) Organ Size
11. (英) Spermatogenesis
12. (英) Spermatogonia
13. (英) Spermatozoa
14. (英) Testis

1. (英) Article.PublicationTypeList.PublicationType: Journal Article