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著作: [高橋 光彦]/[油形 公則]/[松井 好人]/Abbaspour Aziz/[髙田 信二郎]/[安井 夏生]/Bisphosphonate Modulates Morphological and Mechanical Properties in Distraction Osteogenesis through Inhibition of Bone Resorption./[Bone]

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EID
166269
EOID
803020
Map
0
LastModified
2015年11月26日(木) 17:00:10
Operator
三木 ちひろ
Avail
TRUE
Censor
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Owner
安井 夏生
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.大学院ヘルスバイオサイエンス研究部(2004年4月1日〜2015年3月31日)
著者 必須
  1. 高橋 光彦
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 油形 公則
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 松井 好人
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Abbaspour Aziz
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 髙田 信二郎
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 安井 夏生
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Bisphosphonate Modulates Morphological and Mechanical Properties in Distraction Osteogenesis through Inhibition of Bone Resorption.

副題 任意
要約 任意

(英) Despite the general clinical acceptance of distraction osteogenesis and much attention to bone formation in this method, little is recognized about activated bone resorption in the regenerated bone. The purpose of this study was to demonstrate the simultaneously activated bone resorption with activated bone formation and to investigate the role and efficacy of bisphosphonate in distraction osteogenesis. Left tibiae of 54 immature rabbits were lengthened for 3 weeks at a rate of 0.7 mm/day after a 1-week lag. Regenerated bone was quantitatively investigated by radiographic bone density, bone histomorphometry, and three-point bending testing. Animals received either vehicle or nitrogen-containing bisphosphonate (N-BP), YM529/ONO5920 at doses of 0.4 mg/kg/w or 0.004 mg/kg/w for 6 weeks. Regenerated bone of the vehicle group showed a radiologically characteristic zone structure containing the osteopenic zones adjacent to the sclerotic zones. The regenerated bone of the 0.4-mg/kg/w group showed no osteopenic zones during the course and eventually became homogeneously radiodense. The bone volume corresponding to the osteopenic zone of this group was 5.6-fold greater compared with that of the vehicle group. The lengthened bone strength of this group was 3.3-fold greater in ultimate force than that of the vehicle group and equivalent to the contralateral tibia. The 0.004-mg/kg/w group had no substantial differences compared with the vehicle group, despite radiological enhancement of the mineralized front as well as somewhat delayed bone resorption. These results demonstrate that not only bone formation but also bone resorption is highly activated in the regenerated bone, implying high bone turnover. Sufficient N-BP caused a notable modulation in morphological properties of the regenerated bone through inhibition of highly activated bone resorption and eventually increased mechanical properties.

キーワード 推奨
  1. (英) Absorptiometry, Photon
  2. (英) Animals
  3. (英) Bone Resorption
  4. (英) Calcification, Physiologic
  5. (英) Diphosphonates
  6. (英) Male
  7. (英) Osteogenesis
  8. (英) Rabbits
発行所 推奨
誌名 必須 Bone(International Bone and Mineral Society)
(pISSN: 8756-3282, eISSN: 1873-2763)
ISSN 任意 8756-3282
ISSN: 8756-3282 (pISSN: 8756-3282, eISSN: 1873-2763)
Title: Bone
Title(ISO): Bone
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 39
必須 3
必須 573 581
都市 任意
年月日 必須 2006年 1月 1日
URL 任意
DOI 任意 10.1016/j.bone.2006.03.010    (→Scopusで検索)
PMID 任意 16713413    (→Scopusで検索)
NAID 任意
WOS 任意 000240113900017
Scopus 任意 2-s2.0-33746609766
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Orthopedics, Institute of Health Biosciences, the University of Tokushima Graduate School, 3-18-15, Kuramoto, Tokushima 770-8503, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't