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著作: [後藤田 貴子]/[徳永 逸夫]/[北村 修]/[久保 真一]/Toluene inhalation induced neuronal damage in the spinal cord and changes of neurotrophic factors in rat/[Legal Medicine]

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EID
165278
EOID
781170
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LastModified
2015年6月18日(木) 15:49:14
Operator
三木 ちひろ
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Owner
[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.感覚運動系病態医学講座(2004年4月1日〜)
著者 必須
  1. 後藤田 貴子
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 徳永 逸夫
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 北村 修
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 久保 真一
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Toluene inhalation induced neuronal damage in the spinal cord and changes of neurotrophic factors in rat

副題 任意
要約 任意

(英) We investigated the effects of toluene inhalation on neurons and neurotrophic factors in the spinal cord and the relationship between them. Male Wistar rats were exposed to toluene (1500ppm for 4h per day) for 7 days. To observe damage of the neurons in spinal cord with the toluene, expression of microtubule associated protein 2 (MAP2) and 70kDa heat shock protein (HSP70) in spinal cord were performed by immunohistochemistry. MAP2 was degraded and HSP70-immunoreactivity was enhanced in nerve cell bodies of the gray matter in toluene inhalation group. Immunoreactivity of glial fibrillary acidic protein (GFAP), a marker of astrocytes, was enhanced in the toluene-treated group. Furthermore, glial cell line-derived neurotrophic factor (GDNF)- and brain-derived neurotrophic factor (BDNF)-immunoreactivity in spinal cord were slightly decreased in the treated group. In addition, the concentrations of GDNF and BDNF in the spinal cord were determined using enzyme linked immunosorbent assay (ELISA). Concentration of GDNF was reduced significantly by toluene exposure. BDNF also reduced, but not significantly. The toluene inhalation caused the damage of the neuron in the spinal cord, which was accompanied by the decrease in the neurotrophic factors, such as BDNF and GDNF.

キーワード 推奨
  1. (英) Administration, Inhalation
  2. (英) Animals
  3. (英) Biological Markers
  4. (英) Brain-Derived Neurotrophic Factor
  5. (英) Enzyme-Linked Immunosorbent Assay
  6. (英) Forensic Toxicology
  7. (英) Glial Cell Line-Derived Neurotrophic Factor
  8. (英) Glial Fibrillary Acidic Protein
  9. (英) HSP70 Heat-Shock Proteins
  10. 免疫組織化学(immunohistochemistry)
  11. (英) Male
  12. (英) Microtubule-Associated Proteins
  13. (英) Neurons
  14. (英) Rats
  15. (英) Rats, Wistar
  16. (英) Solvents
  17. 脊髄(spinal cord)
  18. (英) Toluene
発行所 推奨 Elsevier(->組織[Elsevier Science])
誌名 必須 Legal Medicine(日本法医学会)
(pISSN: 1344-6223, eISSN: 1873-4162)
ISSN 任意 1344-6223
ISSN: 1344-6223 (pISSN: 1344-6223, eISSN: 1873-4162)
Title: Legal medicine (Tokyo, Japan)
Title(ISO): Leg Med (Tokyo)
Publisher: Elsevier BV
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 9
必須 3
必須 123 127
都市 任意
年月日 必須 2007年 3月 初日
URL 任意
DOI 任意 10.1016/j.legalmed.2006.11.014    (→Scopusで検索)
PMID 任意 17197224    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-33947321290
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Forensic Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article