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著作: Murakami Shinsuke/Nagaya Noritoshi/Itoh Takefumi/[岩瀬 俊]/Fujisato Toshiya/Nishioka Keisuke/Hamada Kaoru/[寒川 賢治]/Kimura Hiroshi/Adrenomedullin Regenerates Alveoli and Vasculature in Elastase-induced Pulmonary Emphysema in Mice/[American Journal of Respiratory and Critical Care Medicine]

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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Murakami Shinsuke
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Nagaya Noritoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Itoh Takefumi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 岩瀬 俊
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Fujisato Toshiya
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Nishioka Keisuke
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Hamada Kaoru
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 寒川 賢治(国立循環器病センター研究所)
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Kimura Hiroshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Adrenomedullin Regenerates Alveoli and Vasculature in Elastase-induced Pulmonary Emphysema in Mice

副題 任意
要約 任意

(英) RATIONALE: Adrenomedullin, a potent vasodilator peptide, regulates cell growth and survival. However, whether adrenomedullin contributes to lung regeneration remains unknown. OBJECTIVES: To investigate whether adrenomedullin influences the kinetics of bone marrow cells, and whether adrenomedullin promotes regeneration of alveoli and vasculature and thereby improves lung structure and function in elastase-induced emphysema in mice. METHODS: Adrenomedullin or vehicle was randomly administered to C57BL/6 mice for 5 days. We counted the numbers of mononuclear cells and stem cell antigen-1-positive cells in circulating blood. After intratracheal injection of elastase or saline, mice were randomized to receive continuous infusion of adrenomedullin or vehicle for 14 days. Functional and histologic analyses were performed 28 days after treatment. RESULTS: Twenty-eight days after elastase injection, destruction of the alveolar walls was observed. However, adrenomedullin infusion significantly inhibited the increase in lung volume, static lung compliance, and mean linear intercept in mice given elastase. Adrenomedullin increased the numbers of mononuclear cells and stem cell antigen-1-positive cells in circulating blood. Adrenomedullin significantly increased the number of bone marrow-derived cells incorporated into the elastase-treated lung. Some of these cells were positive for cytokeratin or von Willebrand factor. Infusion of adrenomedullin after the establishment of emphysema also had beneficial effects on lung structure and function. In vitro, addition of adrenomedullin attenuates elastase-induced cell death in alveolar epithelial cells and endothelial cells. CONCLUSIONS: Adrenomedullin improved elastase-induced emphysema at least in part through mobilization of bone marrow cells and the direct protective effects on alveolar epithelial cells and endothelial cells.

キーワード 推奨
  1. (英) bone marrow cells
  2. 細胞増殖·分化(cell proliferation and differentiation)
  3. (英) mobilization
  4. (英) regeneration
発行所 推奨
誌名 必須 American Journal of Respiratory and Critical Care Medicine(American Thoracic Society/American Lung Association)
(pISSN: 1073-449X, eISSN: 1535-4970)
ISSN 任意 1073-449X
ISSN: 1073-449X (pISSN: 1073-449X, eISSN: 1535-4970)
Title: American journal of respiratory and critical care medicine
Title(ISO): Am J Respir Crit Care Med
Publisher: American Thoracic Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 172
必須 5
必須 581 589
都市 任意
年月日 必須 2005年 9月 1日
URL 任意 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15947283
DOI 任意 10.1164/rccm.200409-1280OC    (→Scopusで検索)
PMID 任意 15947283    (→Scopusで検索)
CRID 任意
WOS 任意 000231574500011
Scopus 任意
評価値 任意
被引用数 任意 7
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Evaluation Studies

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't