徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: Hanabusa Kenichiro/Nagaya Noritoshi/[岩瀬 俊]/Itoh Takefumi/Murakami Shinsuke/Shimizu Yoshito/Taki Waro/Miyatake Kunio/[寒川 賢治]/Adrenomedullin Enhances Therapeutic Potency of Mesenchymal Stem Cells After Experimental Stroke in Rats/[Stroke]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
163658
EOID
849191
Map
0
LastModified
2017年3月6日(月) 11:43:29
Operator
三木 ちひろ
Avail
TRUE
Censor
0
Owner
[科長]/[徳島大学.病院.診療科.内科]
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Hanabusa Kenichiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Nagaya Noritoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 岩瀬 俊
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Itoh Takefumi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Murakami Shinsuke
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Shimizu Yoshito
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Taki Waro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Miyatake Kunio
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 寒川 賢治(国立循環器病センター研究所)
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Adrenomedullin Enhances Therapeutic Potency of Mesenchymal Stem Cells After Experimental Stroke in Rats

副題 任意
要約 任意

(英) Background and Purpose Adrenomedullin (AM) induces angiogenesis and inhibits cell apoptosis through the phosphatidylinositol 3-kinase/Akt pathway. Transplantation of mesenchymal stem cells (MSCs) has been shown to improve neurological deficits after stroke in rats. We investigated whether AM enhances the therapeutic potency of MSC transplantation. Methods Male Lewis rats (n=100) were subjected to 2-hour middle cerebral artery occlusion. Immediately after reperfusion, rats were assigned randomly to receive intravenous transplantation of MSCs plus subcutaneous infusion of AM for 7 days (MSC+AM group), AM infusion alone (AM group), MSC transplantation alone (MSC group), or vehicle infusion (control group). Neurological and immunohistological assessments were performed to examine the effects of these treatments. Results Some engrafted MSCs were positive for neuronal and endothelial cell markers, although the number of differentiated MSCs did not differ significantly between the MSC and MSC+AM groups. The neurological score significantly improved in the MSC, AM, and MSC+AM groups compared with the control group. Importantly, improvement in the MSC+AM group was significantly greater than that in the MSC and AM groups. There was marked induction of angiogenesis in the ischemic penumbra in the MSC+AM group, followed by the AM, MSC, and control groups. AM infusion significantly inhibited apoptosis of transplanted MSCs. As a result, the number of engrafted MSCs in the MSC+AM group was significantly higher than that in the MSC group. Conclusions AM enhanced the therapeutic potency of MSCs, including neurological improvement, possibly through inhibition of MSC apoptosis and induction of angiogenesis.

キーワード 推奨
  1. (英) Adrenomedullin
  2. (英) Animals
  3. アポトーシス(apoptosis)
  4. (英) Body Weight
  5. (英) Cell Transplantation
  6. (英) Disease Models, Animal
  7. 免疫組織化学(immunohistochemistry)
  8. (英) In Situ Nick-End Labeling
  9. (英) Infarction, Middle Cerebral Artery
  10. 虚血(ischemia)
  11. (英) Male
  12. (英) Mesenchymal Stem Cell Transplantation
  13. (英) Mesenchymal Stem Cells
  14. (英) Neovascularization, Pathologic
  15. (英) Neurons
  16. (英) Peptides
  17. (英) Phosphatidylinositol 3-Kinases
  18. (英) Rats
  19. (英) Rats, Inbred Lew
  20. (英) Stem Cells
  21. (英) Stroke
  22. (英) Time Factors
発行所 推奨
誌名 必須 Stroke([American Heart Association])
(pISSN: 0039-2499, eISSN: 1524-4628)
ISSN 任意 1524-4628
ISSN: 0039-2499 (pISSN: 0039-2499, eISSN: 1524-4628)
Title: Stroke
Title(ISO): Stroke
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 36
必須 4
必須 853 858
都市 任意
年月日 必須 2005年 4月 初日
URL 任意 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15746464
DOI 任意 10.1161/01.STR.0000157661.69482.76    (→Scopusで検索)
PMID 任意 15746464    (→Scopusで検索)
CRID 任意
WOS 任意 000228039700035
Scopus 任意 2-s2.0-16844380263
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't