163021: [柏田良樹]/Sekiya, Michiko/Yamazaki, Kimihisa/Ikeshiro, Yasumasa/Fujioka, Toshihiro/Yamagishi, Takashi/Kitagawa, Shuji/[高石喜久]/Triterpenoids from the Floral Spikes of Betula platyphylla var. japonica and Their Reversing Activity against Multidrug-Resistant Cancer Cells/[Journal of Natural Products]

著作: [柏田良樹]/Sekiya, Michiko/Yamazaki, Kimihisa/Ikeshiro, Yasumasa/Fujioka, Toshihiro/Yamagishi, Takashi/Kitagawa, Shuji/[高石喜久]/Triterpenoids from the Floral Spikes of Betula platyphylla var. japonica and Their Reversing Activity against Multidrug-Resistant Cancer Cells/[Journal of Natural Products]

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EID: 163021
EOID: 656331
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LastModified: 2012年8月31日(金) 15:18:49
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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Peer Review

カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

徳島大学.大学院ヘルスバイオサイエンス研究部.創薬資源科学部門.資源分子探索学講座(2004年4月1日〜)

著者

必須

柏田良樹

役割任意

貢献度任意

学籍番号推奨
(英) Sekiya, Michiko

役割任意

貢献度任意

学籍番号推奨
(英) Yamazaki, Kimihisa

役割任意

貢献度任意

学籍番号推奨
(英) Ikeshiro, Yasumasa

役割任意

貢献度任意

学籍番号推奨
(英) Fujioka, Toshihiro

役割任意

貢献度任意

学籍番号推奨
(英) Yamagishi, Takashi

役割任意

貢献度任意

学籍番号推奨
(英) Kitagawa, Shuji

役割任意

貢献度任意

学籍番号推奨
高石喜久([徳島大学.デザイン型AI教育研究センター])

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Triterpenoids from the Floral Spikes of Betula platyphylla var. japonica and Their Reversing Activity against Multidrug-Resistant Cancer Cells

副題

任意

要約

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(英) Four new triterpenes, together with 16 known triterpenes, were isolated from the floral spikes of Betula platyphylla var. japonica in a search for compounds capable of reversing multidrug resistance in cancer cells. The structures of the new triterpenes were elucidated as 3,4-seco-olean-4(23),13(18)-dien-3-oic acid (1), 3,4-seco-urs-4(23),20(30)-dien-3-oic acid (2), 3-O-methylmalonylepiocotillol II (6), and 3-O-methylmalonylcabraleahydroxylactone (16) by spectroscopic examination. The cytotoxicity of the isolated triterpenes against human cancer cell lines as well as multidrug-resistant cancer cell lines was evaluated. Most of the isolated triterpenes showed very weak cellular toxicities. Although no discernible differences were found in the cytotoxicities for the tested compounds against sensitive and resistant cell lines, the cytotoxicities for several triterpenes against multidrug-resistant cancer cell lines (KB-C2 or K562/Adr) were enhanced in the presence of nontoxic concentrations of colchicine or doxorubicin. Compound 10 reversed the cytotoxicity of colchicine against KB-C2 cells at 8.1 microM and showed comparable potency to 5 microM verapamil.

キーワード

推奨

(英) Antineoplastic Agents, Phytogenic
(英) Betula
(英) Colchicine
(英) Drug Resistance, Multiple
(英) Drug Resistance, Neoplasm
(英) Drug Screening Assays, Antitumor
(英) Humans
(英) Japan
(英) KB Cells
(英) Molecular Structure
(英) Triterpenes

発行所

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誌名

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Journal of Natural Products([アメリカ化学会])

(pISSN: 0163-3864, eISSN: 1520-6025)

ISSN	任意	0163-3864 ISSN: 0163-3864 (pISSN: 0163-3864, eISSN: 1520-6025) Title: Journal of natural products Title(ISO): J Nat Prod Publisher: American Chemical Society (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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623 627

都市

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年月日

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2007年 4月初日

URL

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DOI

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10.1021/np060631s (→Scopusで検索)

PMID

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17346076 (→Scopusで検索)

CRID

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WOS

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Scopus

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評価値

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被引用数

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指導教員

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備考

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(英) Article.Affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan. kasiwada@ph.tokushima-u.ac.jp
(英) Article.PublicationTypeList.PublicationType: Journal Article

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