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著作: Chiari PC/Pagel PS/[田中 克哉]/Krolikowski JG/Ludwig LM/Trillo RA/Puri N/Kersten JR/Warltier DC/Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits./[Anesthesiology]

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EID
162971
EOID
685921
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LastModified
2013年4月30日(火) 21:30:17
Operator
大家 隆弘
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Owner
田中 克哉
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
  1. Medical College of Wisconsin
著者 必須
  1. (英) Chiari PC
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    貢献度 任意
    学籍番号 推奨
  2. (英) Pagel PS
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  3. 田中 克哉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Krolikowski JG
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Ludwig LM
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    学籍番号 推奨
  6. (英) Trillo RA
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    貢献度 任意
    学籍番号 推奨
  7. (英) Puri N
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Kersten JR
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Warltier DC
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    学籍番号 推奨
題名 必須

(英) Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits.

副題 任意
要約 任意

(英) Preconditioning against myocardial infarction by volatile anesthetics is well known. The authors tested the hypothesis that new emulsified formulations of halogenated anesthetics administered intravenously reduce myocardial infarct size when administered either 1 or 24 h before prolonged ischemia and reperfusion. Pentobarbital-anesthetized rabbits (n = 39) were instrumented for measurement of hemodynamics and randomly assigned to receive intravenous saline (control), lipid vehicle, or infusions (3.5 ml . kg . h for 30 min) of emulsified isoflurane (6.9%), enflurane (7.1%), or sevoflurane (7.5%). Infusions were discontinued 30 min before a 30-min coronary occlusion and 3 h of reperfusion. In three additional groups, conscious rabbits (n = 21) received saline, lipid vehicle, or emulsified sevoflurane (7.5%) infusions (3.5 ml . kg . h for 30 min) 24 h before ischemia and reperfusion. Infarct size was determined using triphenyltetrazolium staining. Lipid vehicle produced transient increases in heart rate, whereas emulsified volatile anesthetics had no effect on hemodynamics before coronary occlusion. Lipid vehicle did not affect infarct size (38 +/- 2% of the area at risk; mean +/- SEM) as compared with saline control (41 +/- 4%). In contrast, emulsified isoflurane, enflurane, and sevoflurane reduced infarct size (20 +/- 3%, 20 +/- 3%, and 21 +/- 2% of the area at risk, respectively; P < 0.05). Administration of lipid vehicle or emulsified sevoflurane did not produce sedation or respiratory depression in conscious rabbits. Emulsified sevoflurane (18 +/- 2%) but not lipid vehicle (44 +/- 2%) reduced infarct size as compared with control in delayed preconditioning experiments. Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction.

キーワード 推奨
  1. (英) Anesthetics, Inhalation
  2. (英) Anesthetics, Intravenous
  3. (英) Animals
  4. (英) Blood Gas Analysis
  5. (英) Chemistry, Pharmaceutical
  6. (英) Emulsions
  7. (英) Enflurane
  8. (英) Excipients
  9. (英) Hemodynamics
  10. (英) Ischemic Preconditioning, Myocardial
  11. (英) Isoflurane
  12. (英) Male
  13. (英) Methyl Ethers
  14. (英) Myocardial Infarction
  15. (英) Myocardial Reperfusion Injury
  16. (英) Myocardium
  17. (英) Rabbits
発行所 推奨
誌名 必須 Anesthesiology([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)
ISSN 任意 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 101
必須 5
必須 1160 1166
都市 任意
年月日 必須 2004年 11月 初日
URL 任意
DOI 任意 10.1097/00000542-200411000-00016    (→Scopusで検索)
PMID 任意 15505452    (→Scopusで検索)
NAID 任意
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Scopus 任意
評価値 任意 ****
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指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Anesthesiology and Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.