著作: Watanabe Tomonori/[野村 昌弘]/[中安 紀美子]/[河野 智仁]/[伊東 進]/[中屋 豊]/Relationships between thermic effect of food insulin resistance and autonomic nervous activity./[The Journal of Medical Investigation : JMI]
(英) Relationships between thermic effect of food insulin resistance and autonomic nervous activity.
(英) The thermic effect of food (TEF) is higher in lean than in obese human subjects. Relationships between TEF and insulin resistance during meals, from the point of view of autonomic nervous activity, were evaluated. Autonomic nervous activity was evaluated in 20 young adults using the spectral analysis of heart rate variability from one hour before to two hours after a meal. Heart rate data were analyzed based on low frequency components (LF power, 0.04-0.15 Hz), high frequency components (HF power, 0.15-0.40 Hz), and LF/HF ratios. Energy expenditure and the TEF were measured 30 min after a meal. Homeostasis model of insulin resistance index (HOMA-IR) was also measured. The LF/HF ratio was significantly increased 30 min after a meal (p<0.05). No correlation between LF power and HF power with TEF was found, but the LF/HF ratio was significantly and positively correlated with TEF (r=+0.56, p<0.05). Moreover, a significant negative correlation was found between the HOMA-IR and TEF (r=-0.601, p<0.05). The findings suggest that a reduction in insulin sensitivity induces a poor response of sympathetic nervous activity in the postprandial phase and a reduction in postprandial energy expenditure.
The Journal of Medical Investigation : JMI([徳島大学.医学部])
|年月日||必須||2006年 2月 初日|