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著作: Ozaki Y/[野村 昌弘]/Nakayama T/Ogata T/[中安 紀美子]/[中屋 豊]/[伊東 進]/Effects of thrombus suction therapy on myocardial blood flow disorders in males with acute inferior myocardial infarction./[The Journal of Medical Investigation : JMI]

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162940
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878473
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2017年12月4日(月) 14:07:53
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[学科長]/[徳島大学.医学部.医科栄養学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.医療栄養科学講座(2004年4月1日〜)
著者 必須
  1. (英) Ozaki Y
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 野村 昌弘
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Nakayama T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Ogata T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 中安 紀美子
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 中屋 豊
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 伊東 進
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Effects of thrombus suction therapy on myocardial blood flow disorders in males with acute inferior myocardial infarction.

副題 任意
要約 任意

(英) Several studies have reported that the use of a distal protection device decreases the incidence of slow-flow and/or no-reflow in patients with myocardial infarctions. In the present study, we investigated the influence of a RESCUE/Thrombuster system and a PercuSurge GuardWire catheter on coronary microcirculation disorders in patients with acute myocardial infarction using the natriuretic polypeptide (ANP), the brain natriuretic peptide (BNP), and (99m)Tc-tetrofosmin myocardial scintigraphy (TF). The group consisted of a 77 patients with initial inferior myocardial infarction who had undergone emergency coronary angioplasty. The patients were randomly divided into: Group D (n=28), in which a direct stent alone was inserted, Group R/T (n=25), in which a stent was inserted after RESCUE system or a Thrombuster system was performed, and Group P (n=24), in which a stent was inserted after thrombus suction using a PercuSurge GuardWire catheter. Patients with coronary slow-flow/no-reflow were 3, 2 and 0 cases in Group D, Group R / T and Group P, respectively. In the present study, patients with good-reflow were enrolled in order to investigate the coronary microcirculation disorder in patients with visually similar coronary blood flow obtained in coronary angiography after percutaneous coronary reperfusion therapy. TF myocardial scintigraphy was performed 10+/-3 days after admission. Bull's eye images were divided into 8 sections, and each section was evaluated in 4 grades. The grade of each segment was regarded as the defect score. The results were compared with the database prepared based on bull's eye maps from 50 healthy adults in our hospital, and count areas of -2 x SD (standard deviation) or less were calculated as the extent score (%), reflecting the area in which myocardial blood flow was decreased. The extent and severity scores in Groups P and R/T were significantly lower than those in Group D. Coronary angiography at the chronic stage (6 months after surgery) showed the patency of the responsible vascular lesion in all patients. However, the ANP, BNP, cardiac index, and pulmonary capillary wedge pressure (PCWP) were significantly improved in Groups R/T and P, compared to Group D (p<0.01). These results suggest that the use of a RESCUE/Thrombuster system and a PercuSurge GuardWire catheter system in patients with acute inferior wall infarction improves coronary microcirculation disorders and acute- to chronic-phase cardiac function.

キーワード 推奨
  1. (英) Aged
  2. (英) Atrial Natriuretic Factor
  3. (英) Coronary Circulation
  4. (英) Humans
  5. (英) Male
  6. (英) Middle Aged
  7. (英) Myocardial Infarction
  8. (英) Natriuretic Peptide, Brain
  9. (英) Stents
  10. (英) Suction
  11. (英) Thrombectomy
  12. (英) Thrombosis
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 53
必須 1-2
必須 167 173
都市 任意
年月日 必須 2006年 2月 初日
URL 任意
DOI 任意 10.2152/jmi.53.167    (→Scopusで検索)
PMID 任意 16538011    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-33645808499
機関リポジトリ 110803
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Internal Medicine, Kochi Red Cross Hospital, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial