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著作: Kawaguchi T/[野村 昌弘]/Tujikawa T/[中屋 豊]/[伊東 進]/(123)I-metaiodo-benzylguanidine myocardial scintigraphy in the Brugada-type ECG./[The Journal of Medical Investigation : JMI]

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162932
EOID
878465
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2017年12月4日(月) 14:07:48
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[学科長]/[徳島大学.医学部.医科栄養学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.医療栄養科学講座(2004年4月1日〜)
著者 必須
  1. (英) Kawaguchi T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 野村 昌弘
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Tujikawa T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 中屋 豊
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 伊東 進
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) (123)I-metaiodo-benzylguanidine myocardial scintigraphy in the Brugada-type ECG.

副題 任意
要約 任意

(英) The degree of ST-segment elevation and amplitude of J waves, which may change in patients with the Brugada-type electrocardiogram (ECG) over time, are influenced by autonomic nervous activity and the administration of antiarrhythmic drugs. In the present study, we evaluated whether the shape of ST-segment elevation in patients with a Brugada-type ECG might alter the parameters of an 123I-MIBG myocardial scintigraphy and body surface signal-averaged ECG (SAECG). The subjects consisted of 12 patients with a Brugada-type ECG and 15 healthy volunteers (N group). The patients with a Brugada-type ECG were classified into the following 2 groups based on the type of ST-segment elevation: 6 patients with the coved type ST-segment elevation (C group), and 6 patients with the saddle-back type ST-segment elevation (S group). Planar and SPECT images were obtained 15 minutes (early images) and 3 hours (delayed images) after the administration of 123I-MIBG, respectively. In addition, the washout rate (% WR) of 123I-MIBG was obtained in a bull's eye map of the SPECT image. There were no significant differences in the early H/M ratio between the C and S groups. In the C group, however, there were some patients who showed a decreased accumulation or defect of 123I-MIBG in the planar and SPECT images. Furthermore, in contrast to the N and S groups, the C group showed a decreased delayed H/M ratio and increased % WR. SAECG did not show any significant differences between the S and C groups. These results of the present study suggest that the shape of ST-segment elevation may be associated with myocardial autonomic nervous function. In addition, the electric heterogeneity of the action potential in the right ventricular epicardial myocardium, which is frequently influenced by autonomic nervous activity, is closely associated with the development of Brugada syndrome.

キーワード 推奨
  1. (英) 3-Iodobenzylguanidine
  2. (英) Adult
  3. (英) Autonomic Nervous System
  4. (英) Case-Control Studies
  5. (英) Electrocardiography
  6. (英) Female
  7. 心臓(heart)
  8. (英) Humans
  9. (英) Iodine Radioisotopes
  10. (英) Male
  11. (英) Middle Aged
  12. (英) Radiopharmaceuticals
  13. (英) Ventricular Fibrillation
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 53
必須 1-2
必須 95 102
都市 任意
年月日 必須 2006年 2月 初日
URL 任意
DOI 任意 10.2152/jmi.53.95    (→Scopusで検索)
PMID 任意 16538001    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-33645808726
機関リポジトリ 110793
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article