徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.器官病態修復医学講座(2004年4月1日〜)

1. 黒部 裕嗣

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. 北市 隆

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. (英) Shimahara Yusuke

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Kanemura Takeyuki

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. 神原 保

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. (英) Kurushima Atsushi

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. 加納 正志

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 堀 隆樹

   役割	任意
   貢献度	任意
   学籍番号	推奨

9. 吉田 誉

   役割	任意
   貢献度	任意
   学籍番号	推奨

10. (英) Urata Masahiro

    役割	任意
    貢献度	任意
    学籍番号	推奨

11. 北川 哲也

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) Significance of Peritoneal Fluid Drainage in Management After Repair of Complex Heart Defects in Infancy

(英) Cytokine Dynamics In Vivo

(英) In vivo redundancy of pro-inflammatory cytokines results in a vicious cycle of systemic inflammatory response syndrome and low cardiac output syndrome (LOS). The purpose of this study was to elucidate the influence of peritoneal fluid (PF) drainage on cytokine dynamics in vivo and the significance of early induction for infants with LOS. Seven infants, who underwent early PF drainage to manage LOS after repair of complex heart defects under cardiopulmonary bypass, were enrolled. The serum and PF levels of the pro- and antiinflammatory cytokines, interleukin (IL)-6, -8, -10 and tumor necrosis factor (TNF)-alpha, were measured during the perioperative period. Clinical outcomes were observed simultaneously. There were no cases of early or late death, or infectious complications. Drainage volume of PF peaked just after operation, and decreased completely. The amount of proinflammatory cytokines in the PF increased for 3 days after operation. Of the proinflammatory cytokines in the PF IL-6 increased the earliest and cleared the fastest. The amount of cleared IL-8 and TNF-alpha peaked on the 3rd postoperative day and resembled the course of C-reactive protein (CRP). Serum levels of CRP and proinflammatory cytokines in patients with PF drainage decreased significantly more than those without PF drainage. Early initiation of PF drainage is useful in the postoperative critical care of infants with LOS by improving cytokine dynamics in vivo, although there are differences between the severity of patients undergoing PF drainage and those who do not.

1. (英) Ascitic Fluid
2. (英) C-Reactive Protein
3. (英) Cardiac Output, Low
4. (英) Cardiopulmonary Bypass
5. 細胞質分裂(cytokinesis)
6. (英) Drainage
7. (英) Female
8. (英) Heart Defects, Congenital
9. (英) Humans
10. 小児(infant)
11. (英) Male
12. (英) Postoperative Care
13. (英) Postoperative Period

1. (英) Article.Affiliation: Department of Cardiovascular Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article