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著作: Tanaka Yasushi/[佐野 壽昭]/[銭 志栄]/[廣川 満良]/Expression of adhesion molecules and cytokeratin 20 in merkel cell carcinomas.Endocr Pathol/[Endocrine Pathology]

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2012年9月11日(火) 15:23:03
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三木 ちひろ
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[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Tanaka Yasushi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 佐野 壽昭
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 銭 志栄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 廣川 満良
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Expression of adhesion molecules and cytokeratin 20 in merkel cell carcinomas.Endocr Pathol

副題 任意
要約 任意

(英) Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin. MCCs often show characteristic paranuclear dot-like immunopositivity for cytokeratin 20 (CK20), a globular aggregation of CK20 intermediate filaments. These aggregates typically form rhabdoid features and fibrous bodies and may be associated with a down-regulation in adhesion molecules (AMs). To date, the relationship between the expression of AMs and CK20 and clinicopathological findings in MCC has not been well examined. In this immunohistochemical study, we assessed the expression of AMs, CK20, and chromogranin A (CgA) on MCCs in 8 men and 23 women with this disease, and also characterized their clinicopathological features. This study is the largest of its kind that has been undertaken to date in Japanese patients. Compared to normal tissue, E-cadherin and alpha- and beta-catenins showed reduced membranous expression in 95.7%, 46.7%, and 45.2% of MCCs, respectively. Nuclear E-cadherin localization was seen in four tumors, all of which predominantly showed a CK20 dot pattern. However, there was no significant relationship between the membranous expression of AMs and a CK20 dot pattern. E-cadherin expression was significantly lower in tumors of > or =2 cm, and tumors negative for E-cadherin more frequently developed outside of the head and neck than within those regions. CgA was more intensely expressed in tumors with uniform nuclei and a dense lymphocytic infiltrate than in those that showed pleomorphisms and that had few, if any, infiltrating lymphocytes. These findings suggest that MCCs have a reduced expression of AMs and that down-regulation of E-cadherin expression may correlate with increased tumor aggressiveness. The fact that no significant relationship was demonstrable between the membranous expression of AMs and the CK20 expression pattern suggests that the mechanism of aggregation of intermediate filaments may be different in different types of tumors.

キーワード 推奨
  1. (英) Aged
  2. (英) Aged, 80 and over
  3. (英) Cadherins
  4. (英) Carcinoma, Merkel Cell
  5. (英) Cell Adhesion Molecules
  6. (英) Chromogranin A
  7. (英) Chromogranins
  8. (英) Cytoskeletal Proteins
  9. (英) Female
  10. (英) Humans
  11. 免疫組織化学(immunohistochemistry)
  12. (英) Intermediate Filament Proteins
  13. (英) Keratin-20
  14. (英) Male
  15. (英) Middle Aged
  16. (英) Skin Neoplasms
  17. (英) Statistics, Nonparametric
  18. (英) Trans-Activators
  19. (英) alpha Catenin
  20. (英) beta Catenin
発行所 推奨
誌名 必須 Endocrine Pathology(Endocrine Pathology Society)
(pISSN: 1046-3976, eISSN: 1559-0097)
ISSN 任意 1046-3976
ISSN: 1046-3976 (pISSN: 1046-3976, eISSN: 1559-0097)
Title: Endocrine pathology
Title(ISO): Endocr Pathol
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 15
必須 2
必須 117 129
都市 任意
年月日 必須 2004年 8月 10日
URL 任意
DOI 任意 10.1385/EP:15:2:117    (→Scopusで検索)
PMID 任意 15299198    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Human Pathology, University of Tokushima School of Medicine, Tokushima 770-8503, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article