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著作: Tsukumo Shin-ichi/Hirose Kayo/[前川 洋一]/Kishihara Kenji/[安友 康二]/Lunatic fringe controls T cell differentiation through modulating Notch signaling./[The Journal of Immunology]

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EID
162824
EOID
669137
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LastModified
2012年11月3日(土) 18:17:47
Operator
大家 隆弘
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安友 康二
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Tsukumo Shin-ichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Hirose Kayo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 前川 洋一
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kishihara Kenji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 安友 康二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Lunatic fringe controls T cell differentiation through modulating Notch signaling.

副題 任意
要約 任意

(英) T cells differentiate from bone marrow-derived stem cells by expressing developmental stage-specific genes. We here searched arrays of genes that are highly expressed in mature CD4-CD8+ (CD8 single-positive (SP)) T cells but little in CD4+CD8+ (double-positive (DP)) cells by cDNA subtraction. Lunatic fringe (Lfng), a modulator of Notch signaling, was identified to be little expressed in DP cells and highly expressed in CD8SP T cell as well as in CD4-CD8- (double-negative (DN)) and mature CD4+CD8- (CD4SP) T cells. Thus, we examined whether such change of expression of Lfng plays a role in T cell development. We found that overexpression of Lfng in Jurkat T cells strengthened Notch signaling by reporter gene assay, indicating that Lfng is a positive regulator for Notch signaling in T cells. The enforced expression of Lfng in thymocytes enhanced the development of immature CD8SP cells but decreased mature CD4SP and CD8SP cells. In contrast, the down-regulation of Lfng in thymocytes suppressed DP cells development due to the defective transition from CD44+CD25- stage to subsequent stage in DN cells. The overexpression of Lfng in fetal liver-derived hemopoietic stem cells enhanced T cell development, whereas its down-regulation suppressed it. These results suggested that the physiological high expression of Lfng in DN cells contributes to enhance T cell differentiation through strengthening Notch signaling. Shutting down the expression of Lfng in DP cells may have a physiological role in promoting DP cells differentiation toward mature SP cells.

キーワード 推奨
  1. (英) Animals
  2. (英) Antigens, CD4
  3. (英) Antigens, CD8
  4. 細胞分化(cell differentiation)
  5. (英) Gene Expression Regulation
  6. (英) Glycosyltransferases
  7. (英) Humans
  8. (英) Jurkat Cells
  9. (英) Mice
  10. (英) Mice, Inbred C57BL
  11. (英) Receptors, Notch
  12. シグナル伝達(signal transduction)
  13. Tリンパ球(T lymphocytes)
  14. (英) Thymus Gland
発行所 推奨
誌名 必須 The Journal of Immunology([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
ISSN 任意 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 177
必須 12
必須 8365 8371
都市 任意
年月日 必須 2006年 12月 15日
URL 任意
DOI 任意
PMID 任意 17142733    (→Scopusで検索)
NAID 任意
WOS 任意 000243416800012
Scopus 任意
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被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Immunology and Parasitology, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't