徳島大学 教育・研究者情報データベース(EDB)

1. (英) Ikemoto Tetsuya

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2. (英) Yamaguchi Takeshi

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3. (英) Morine Yuji

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4. (英) Imura Satoru

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5. (英) Soejima Yuji

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6. (英) Fujii Masahiko

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7. 前川 洋一

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8. 安友 康二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])

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9. (英) Shimada Mitsuo

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(英) Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients.

(英) Further metastasis should be avoided in pancreatic cancer (PC) patients for effective surgical treatment. Regulatory T cells (Foxp3CD4 T cells including CD4CD25 T cells and CD4CD25 T cells) play important roles in tumor immunity. This study aimed to investigate whether regulatory T cells participate in metastasis. Peripheral blood was withdrawn from PC patients, as well as healthy volunteer donors as controls. The peripheral blood mononuclear cells (PBMCs) were subjected to FACScan analysis after labeling with anti-CD4, anti-CD25, and anti-Foxp3 antibodies. Tumor markers, including DUPAN2 and CA19-9, surface markers, such as the CD4/CD8 ratio, and the CD57 cell population were assessed. Clinical stages were classified according to the TNM classification. The Foxp3CD4 T-cell population among the PBMCs was significantly increased in PC patients (8.10% +/- 4.65%) compared with healthy donors (2.47 +/- 0.78%) (P < 0.001). No significant relationships existed for the tumor markers, CD4/CD8 ratio, and CD57 cells. However, a significant correlation was found between Foxp3CD4 T cells among the PBMCs and the TNM stage (P < 0.05). Foxp3CD4 T cells are good markers for metastasis detection in PC patients and more accurate than other conventional tumor markers, especially at advanced stages of the disease.

1. (英) Aged
2. (英) Female
3. (英) Forkhead Transcription Factors
4. (英) Humans
5. (英) Interleukin-2 Receptor alpha Subunit
6. (英) Male
7. (英) Middle Aged
8. (英) Neoplasm Staging
9. (英) Pancreatic Neoplasms
10. (英) T-Lymphocyte Subsets
11. (英) T-Lymphocytes, Regulatory

1. (英) Article.Affiliation: Department of Immunology and Paracytology, Institute of Health Bioscience, Graduate School of Medicine, The University of Tokushima, Kuramoto, Tokushima, Japan. tikemoto@clin.med.tokushima-u.ac.jp

2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't