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著作: Hu Ying/[馬 寧]/Yang Miao/Semba Reiji/Expression and Distribution of Heme Oxygenase-2 mRNA and Protein in Rat Kidney/[The Journal of Histochemistry and Cytochemistry]

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EID
161387
EOID
680122
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LastModified
2013年2月26日(火) 14:25:35
Operator
三木 ちひろ
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Owner
[学科長]/[徳島大学.医学部.医学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Hu Ying
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 馬 寧
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Yang Miao
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Semba Reiji
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Expression and Distribution of Heme Oxygenase-2 mRNA and Protein in Rat Kidney

副題 任意
要約 任意

(英) Recent studies suggest that carbon monoxide (CO), which is formed by the enzyme heme oxygenase (HO) during the conversion of heme to biliverdin, shares some of the chemical and biological properties of nitric oxide (NO) and may play roles similar to those of NO. Heme oxygenase activity in the kidney has been reported for many years, and there are some reports on the expression of mRNA for two HO isozymes (HO-1 and HO-2) and cellular localization of HO-1 protein. However, cellular localization of HO-2 protein in the kidney under normal conditions has not been reported. In the present study we examined the expression and distribution of HO-2 mRNA and HO-2 protein in rat kidney using RNA protection assay and light and electron immunocytochemistry. RNA protection assay confirmed constitutive expression of HO-2 transcript in rat kidney. HO-2 immunoreactivity was selectively found in epithelial cells of the thick ascending limb and distal convoluted tubule, connecting tubule cells, and principal cells of the collecting duct. These results suggest that HO-2 is synthesized in the kidney and that HO-2 in the epithelial cells of renal tubules may serve as a source for CO generation under normal conditions.

キーワード 推奨
  1. (英) Animals
  2. (英) Blotting, Western
  3. (英) Epithelial Cells
  4. 遺伝子発現(gene expression)
  5. (英) Heme Oxygenase (Decyclizing)
  6. 免疫組織化学(immunohistochemistry)
  7. (英) Isoenzymes
  8. (英) Kidney
  9. (英) Kidney Tubules
  10. (英) Kidney Tubules, Distal
  11. (英) Microscopy, Immunoelectron
  12. (英) RNA, Messenger
  13. (英) Rats
  14. (英) Rats, Wistar
発行所 推奨
誌名 必須 The Journal of Histochemistry and Cytochemistry(The Histochemical Society)
(pISSN: 0022-1554, eISSN: 1551-5044)
ISSN 任意 0022-1554
ISSN: 0022-1554 (pISSN: 0022-1554, eISSN: 1551-5044)
Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Title(ISO): J Histochem Cytochem
Publisher: Histochemical Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 46
必須 2
必須 249 256
都市 任意
年月日 必須 1998年 2月 初日
URL 任意
DOI 任意 10.1177/002215549804600214    (→Scopusで検索)
PMID 任意 9446832    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Anatomy, Mie University School of Medicine, Mie, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article