徳島大学 教育・研究者情報データベース(EDB)

1. (英) Nakashima Akio / (読) なかしま あきお

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2. 長谷川 敬展([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])

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3. (英) Mori Saori / (読) もり さおり

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4. (英) Ueno Masaru / (日) 上野 勝 / (読) うえの まさる

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5. (英) Tanaka Shigeyasu / (日) 田中 滋康 / (読) たなか しげやす

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6. (英) Ushimaru Takashi / (日) 丑丸 敬 / (読) うしまる たかし

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7. (英) Sato Shusei

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8. (英) Uritani Masahiro / (日) 瓜谷 真裕 / (読) うりたに まさひろ

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(英) A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.

(英) Schizosaccharomyces pombe isp6(+) gene encodes a vacuolar serine protease, which is specifically induced during nitrogen starvation. An isp6-disruption mutant, isp6Delta, grew normally under normal conditions but was defective in large-scale protein degradation during nitrogen starvation, a hallmark of autophagy. Vacuoles are the organelles for such drastic protein degradation but those of isp6Delta were apparently aberrant. isp6Delta was infertile under nitrogen source-free conditions with poor expression of ste11(+), a gene critical for sexual development. A protein kinase A-disruption mutant, pka1Delta, is prone to sexual development because expression of ste11(+) is derepressed. However, isp6Deltapka1Delta still showed defects in ste11(+) expression and sexual development under nitrogen source-free conditions. isp6Delta and isp6Deltapka1Delta were able to initiate sexual development to produce spores when only a small amount of a nitrogen source was present. Pat1 protein kinase negatively controls meiosis, and a temperature-sensitive mutant of pat1, pat1-114, initiates meiosis irrespective of ploidy at the restrictive temperature. However, isp6Deltapat1-114 did not start meiosis under nitrogen source-free conditions even at the restrictive temperature. These observations suggest that isp6(+) contributes to sexual development by providing a nitrogen source through autophagy.

1. (英) Autophagy
2. (英) Epistasis, Genetic
3. (英) Gene Expression Regulation, Fungal
4. (英) Meiosis
5. (英) Membrane Proteins
6. (英) Nitrogen
7. (英) Schizosaccharomyces
8. (英) Schizosaccharomyces pombe Proteins
9. (英) Serine Endopeptidases
10. (英) Signal Transduction
11. (英) Transcription Factors

1. (英) Article.Affiliation: Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, 422-8539, Shizuoka, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't